{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:25:46Z","timestamp":1764249946010,"version":"3.46.0"},"reference-count":37,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To analyze the association of pathologic\u2010complete\u2010response (PCR) and survival after neoadjuvant concurrent chemo\u2010radiotherapy, we evaluated a large cohort of patients with potentially resectable stage IIIA\u2013IIIC non\u2010small cell lung cancer (NSCLC) treated with a trimodality approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients underwent neoadjuvant induction chemotherapy, followed by concurrent chemo\u2010radiotherapy and surgery. Patients received established imaging, and diagnostics. Leave\u2010one\u2010out cross\u2010validation was employed to identify the most effective prognostic classifier.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Altogether, 403 patients treated between 06\/2000 and 01\/2020 were included. Median follow\u2010up was 111\u2009months (IQR: 71\u2013127\u2009months). PCR was achieved in 34% (137 patients) after neoadjuvant therapy and major\u2010pathologic response without PCR in 30% (MPR\n                      <jats:sub>&gt;\u20090%\u2013\u2264\u200910%<\/jats:sub>\n                      defined as viable cells in &gt;\u20090% and\u2009\u2264\u200910% of the sample). PCR was significantly dependent on histology (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0005) and radiotherapy fractionation schedule (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027). PCR rates were higher for squamous than for non\u2010squamous carcinoma with 46.2% (95% CI: 37.8%\u201354.7%) versus 27.3% (95% CI: 22.0%\u201333.2%). PCR was the most significant prognostic factor for long\u2010term survival with an associated hazard ratio of 0.272 (0.192\u20130.386), while MPR was associated with a hazard ratio of 0.671 (0.498\u20130.905) in comparison to lesser response. Overall survival at 5\/10\u2009years with PCR was 72.9% (95% CI: 64.4%\u201379.6%)\/ 62.8% (53.0%\u201371.1%)\/ event\u2010free survival at 5\u2009years 69.5% (60.9%\u201376.7%). Identified through cross\u2010validation, key prognostic features included PCR, MPR, and treatment period following\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG\u2010PET\/CT\u2010guided staging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Induction chemotherapy followed by chemo\u2010radiotherapy results in high PCR rates. In this investigation, PCR is followed by high event\u2010free and overall survival rates. These data warrant further investigation of chemo\u2010radiotherapy as a significant component of neoadjuvant treatment regimens in trials combined with immunotherapy. This strategy may increase the PCR rates, particularly for patients with more advanced, potentially resectable stage III NSCLC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70183","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T06:37:26Z","timestamp":1763620646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathologic Complete Response Predicts Long\u2010Term Survival Following Neoadjuvant Induction Chemotherapy and Chemo\u2010Radiotherapy in Stage\u2010\n                    <scp>III<\/scp>\n                    Non\u2010Small Cell Lung Cancer"],"prefix":"10.1111","volume":"16","author":[{"given":"Maja","family":"Guberina","sequence":"first","affiliation":[{"name":"Department of Radiotherapy University Hospital Essen  Essen Germany"},{"name":"Medical Faculty University Duisburg\u2010Essen  Essen Germany"},{"name":"National Center for Tumor Diseases (NCT West)  Essen Germany"},{"name":"German Consortium for Translational Cancer Research, Partner Site Essen\/D\u00fcsseldorf  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Metzenmacher","sequence":"additional","affiliation":[{"name":"Medical Faculty University Duisburg\u2010Essen  Essen Germany"},{"name":"National Center for Tumor Diseases (NCT West)  Essen Germany"},{"name":"German Consortium for Translational Cancer Research, Partner Site Essen\/D\u00fcsseldorf  Essen Germany"},{"name":"Department of Medical Oncology, West German Cancer Center University Hospital Essen  Essen Germany"},{"name":"Thoracic Oncology University Medicine Essen \u2010 Ruhrlandklinik, University Hospital  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"P\u00f6ttgen","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy University Hospital Essen  Essen Germany"},{"name":"Medical Faculty University Duisburg\u2010Essen  Essen Germany"},{"name":"National Center for Tumor Diseases (NCT West)  Essen Germany"},{"name":"German Consortium for Translational Cancer Research, Partner Site Essen\/D\u00fcsseldorf  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Wiesweg","sequence":"additional","affiliation":[{"name":"Medical Faculty University Duisburg\u2010Essen  Essen Germany"},{"name":"National Center for Tumor Diseases (NCT West)  Essen Germany"},{"name":"German Consortium for Translational Cancer Research, Partner Site Essen\/D\u00fcsseldorf  Essen Germany"},{"name":"Department of Medical Oncology, West German Cancer Center University Hospital Essen  Essen Germany"},{"name":"Thoracic Oncology University Medicine Essen \u2010 Ruhrlandklinik, University Hospital  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nika","family":"Guberina","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy University Hospital Essen  Essen Germany"},{"name":"Medical Faculty University Duisburg\u2010Essen  Essen Germany"},{"name":"National Center for Tumor Diseases (NCT West)  Essen Germany"},{"name":"German Consortium for Translational Cancer Research, Partner Site Essen\/D\u00fcsseldorf  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Merkel\u2010Jens","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Biometry and Epidemiology University Hospital Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"L\u00fctke\u2010Brintrup","sequence":"additional","affiliation":[{"name":"Medical Faculty University Duisburg\u2010Essen  Essen Germany"},{"name":"Institute of Medical Informatics, Biometry and Epidemiology University Hospital Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Servet","family":"B\u00f6l\u00fckbas","sequence":"additional","affiliation":[{"name":"Medical Faculty University Duisburg\u2010Essen  Essen Germany"},{"name":"National Center for Tumor Diseases (NCT West)  Essen Germany"},{"name":"Department of Thoracic Surgery University Medicine Essen \u2010 Ruhrlandklinik  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfried E. 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