{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:25:47Z","timestamp":1764249947637,"version":"3.46.0"},"reference-count":20,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to clarify the incidences and treatments of enlarged nodules detected using imaging findings during follow\u2010up, surgical outcomes, and prognosis for patients who underwent a second surgery for primary lung cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 236 patients who underwent a second surgery for primary lung cancer (&gt;\u20092\u2009years between first and second surgeries). Group A comprised 205 patients without nodules. Group B comprised 31 patients with nodules that had grown and metachronous lung cancer was suspected; subgroup B1 underwent surgery (23 patients) and subgroup B2 did not (8 patients).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidences of new or enlarged intrapulmonary nodules following the second surgery were 0.0091, 0.015, 0.020, 0.024, and 0.029 after 1, 2, 3, 4, and 5\u2009years, respectively. For the third surgery procedure, 83% of the patients underwent segmentectomy and wide\u2010wedge resection. Ten patients (44%) experienced complications associated with the third surgery including prolonged pulmonary fistulas in 6 patients (26%). The B1 subgroup 30\u2010day mortality rate after the third surgery was 4.3% (1\/23). The 1\u2010, 2\u2010, 3\u2010, 4\u2010, and 5\u2010year survival rates after the second surgery in subgroup B1 were 95.7%, 86.3%, 80.9%, 80.9%, and 60.0%, respectively. No significant difference was observed in prognosis between the B1 and B2 subgroups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.11).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Surgery can be considered effective for third primary lung cancer, notwithstanding associated complications, perioperative mortality, and prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70187","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T05:14:25Z","timestamp":1763356465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tolerability of Surgery by Patients With Third Primary Lung Cancer After Second Primary Lung Cancer Surgery"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7074-7367","authenticated-orcid":false,"given":"Hideomi","family":"Ichinokawa","sequence":"first","affiliation":[{"name":"Department of General Thoracic Surgery Juntendo University Shizuoka Hospital  Shizuoka Japan"},{"name":"Department of General Thoracic Surgery Juntendo University Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Takamochi","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Juntendo University Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Juntendo University Shizuoka Hospital  Shizuoka Japan"},{"name":"Department of General Thoracic Surgery Juntendo University Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Juntendo University Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aritoshi","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Juntendo University Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Juntendo University Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Juntendo University Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,16]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_13_2_1","DOI":"10.1016\/j.athoracsur.2011.02.034"},{"doi-asserted-by":"publisher","key":"e_1_2_13_3_1","DOI":"10.1016\/j.athoracsur.2014.04.098"},{"doi-asserted-by":"publisher","key":"e_1_2_13_4_1","DOI":"10.1378\/chest.07-1390"},{"doi-asserted-by":"publisher","key":"e_1_2_13_5_1","DOI":"10.1016\/j.athoracsur.2019.09.088"},{"doi-asserted-by":"publisher","key":"e_1_2_13_6_1","DOI":"10.1016\/j.athoracsur.2019.06.023"},{"doi-asserted-by":"publisher","key":"e_1_2_13_7_1","DOI":"10.1186\/s12893-019-0643-0"},{"doi-asserted-by":"publisher","key":"e_1_2_13_8_1","DOI":"10.1016\/j.jtcvs.2020.06.124"},{"doi-asserted-by":"publisher","key":"e_1_2_13_9_1","DOI":"10.1186\/s12893-023-02003-9"},{"doi-asserted-by":"publisher","key":"e_1_2_13_10_1","DOI":"10.1016\/S0022-5223(19)40289-4"},{"key":"e_1_2_13_11_1","first-page":"e269S","article-title":"Special Treatment Issues in Non\u2010Small Cell Lung Cancer: Diagnosis and Management of Lung Cancer 3rd Edn American College of Chest Physicians Evidence\u2010Based Clinical Practice Guidelines","volume":"143","author":"Kozower B. D.","year":"2013","journal-title":"Chest"},{"doi-asserted-by":"publisher","key":"e_1_2_13_12_1","DOI":"10.1378\/chest.07-1359"},{"doi-asserted-by":"publisher","key":"e_1_2_13_13_1","DOI":"10.1016\/j.athoracsur.2022.07.025"},{"doi-asserted-by":"publisher","key":"e_1_2_13_14_1","DOI":"10.1186\/s12957-018-1398-2"},{"doi-asserted-by":"publisher","key":"e_1_2_13_15_1","DOI":"10.1093\/ejcts\/ezs063"},{"doi-asserted-by":"publisher","key":"e_1_2_13_16_1","DOI":"10.1016\/S0003-4975(02)03855-9"},{"doi-asserted-by":"publisher","key":"e_1_2_13_17_1","DOI":"10.1016\/j.athoracsur.2013.04.014"},{"doi-asserted-by":"publisher","key":"e_1_2_13_18_1","DOI":"10.1016\/j.jtcvs.2012.10.038"},{"doi-asserted-by":"publisher","key":"e_1_2_13_19_1","DOI":"10.1016\/j.ejca.2014.09.006"},{"doi-asserted-by":"publisher","key":"e_1_2_13_20_1","DOI":"10.1001\/jamaoncol.2018.1258"},{"doi-asserted-by":"publisher","key":"e_1_2_13_21_1","DOI":"10.1007\/s00330-020-07634-7"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.70187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:22:13Z","timestamp":1764249733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.70187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":20,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/1759-7714.70187"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.70187","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"type":"print","value":"1759-7706"},{"type":"electronic","value":"1759-7714"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70187"}}