{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T10:24:38Z","timestamp":1765794278390,"version":"3.48.0"},"reference-count":34,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We previously reported the short\u2010term real\u2010world effectiveness and safety of first\u2010line atezolizumab combined with chemotherapy in patients with extensive\u2010stage small cell lung cancer (ES\u2010SCLC). This study provides an updated analysis of the effectiveness, prognostic factors, and subsequent treatment patterns in first\u2010line immunochemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective multicenter observational study enrolled patients with ES\u2010SCLC, diagnosed at seven university hospitals throughout Korea, between June 2021 and August 2022. Primary outcomes were 1\u2010year overall survival (OS) and progression\u2010free survival (PFS), whereas secondary outcomes included OS, objective response rate, disease control rate, second progression\u2010free survival, and safety, evaluated based on established clinical guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 100 ES\u2010SCLC patients (median age, 69\u2009years) were enrolled, with a median follow\u2010up duration of 26.0\u2009months. The median PFS and OS were 6.2 and 17.1\u2009months, respectively, with a 1\u2010year OS rate of 62.5%. Favorable prognostic factors for OS included partial response (PR) and stable disease (SD) as the best responses (SD: hazard ratio (HR), 0.79; PR: HR, 0.38) and a longer platinum\u2010free interval (HR 0.84). Brain radiotherapy significantly improved OS in patients with brain metastases, whereas thoracic radiotherapy during first\u2010line treatment tended to prolong survival in patients who responded to systemic treatment. Patients receiving second\u2010line treatment after progression presented a significantly longer OS than did those receiving only best supportive care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study outlined the real\u2010world effectiveness and safety of first\u2010line atezolizumab immunochemotherapy for ES\u2010SCLC patients over an extended follow\u2010up, noting that local treatment and post\u2010progression therapy were associated with improved survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70201","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:25:05Z","timestamp":1765524305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extended Follow\u2010Up Analysis of First\u2010Line Atezolizumab in Extensive\u2010Stage Small Cell Lung Cancer: A Real\u2010World Multicenter Prospective Cohort Study"],"prefix":"10.1111","volume":"16","author":[{"given":"Yechan","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3538-1993","authenticated-orcid":false,"given":"Myeong Geun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine  Seoul 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