{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:27:02Z","timestamp":1784690822284,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Locally advanced B\u2010type thymomas frequently present technical challenges for R0 resection. Given the limitations of conventional neoadjuvant therapies, this study investigated glucocorticoids (GCs) as a potential downstaging strategy to improve surgical feasibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A propensity score\u2010matched analysis was conducted in patients with Masaoka\u2010Koga stage III\u2010IV B\u2010type thymomas (2017\u20132024). The intervention cohort (GC\u2009+\u2009Surgery,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936) received oral prednisone acetate (0.6\u2009mg\/kg\/d, maximum dose 50\u2009mg\/d for 2\u20134\u2009weeks) followed by surgery, while matched controls (Surgery,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936) underwent immediate resection. Outcomes included surgical parameters (operative time, blood loss, R0 rates), perioperative complications, and survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Neoadjuvant GCs yielded an objective response rate of 64.8% (13.2% complete response, 51.6% partial response). The GC\u2009+\u2009Surgery cohort demonstrated reduced operative time (182.8 vs. 426.0\u2009min;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and median blood loss (165 vs. 1285\u2009mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), along with increased utilization of VATS approaches (55.6% vs. 13.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). R0 resection rates were 97.2% versus 86.1% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.115), with no R2 resections observed in the GC group. Perioperative complication profiles appeared comparable between groups. At a median follow\u2010up of 52\u2009months, the GC\u2009+\u2009Surgery group showed higher 5\u2010year progression\u2010free survival (83.4% vs. 72.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033), though overall survival differences did not reach statistical significance (94.1% vs. 85.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.272).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest neoadjuvant glucocorticoids may enhance resectability in advanced B\u2010type thymomas, potentially enabling less invasive procedures and improving intermediate\u2010term disease control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70214","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T23:02:23Z","timestamp":1766790143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neoadjuvant Glucocorticoids Facilitate Resection in Advanced B\u2010Type Thymomas: A Propensity\u2010Matched Analysis of Surgical and Survival Outcomes"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6357-5026","authenticated-orcid":false,"given":"Zhen","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingguo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Beijing Tongren Hospital, Capital Medical University  Beijing 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