{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T17:23:25Z","timestamp":1769707405083,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While chemotherapy remains the treatment of choice for mesothelioma, it carries significant toxicities, especially hematological toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted this territory\u2010wide retrospective study in Hong Kong to investigate the prevalence and risk factors of hematological toxicity associated with mesothelioma treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 222 patients were included in the analysis. Lower baseline serum albumin level and more lines of cytotoxic chemotherapy received were risk factors for developing grade 3\u20134 hematological toxicity with aOR of 1.05 (95% CI, 1.02\u20131.09,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and 1.50 (95% CI, 1.03\u20132.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033) respectively. Risk factors for developing neutropenic fever included: diabetes mellitus (aOR\u2009=\u20099.44, 95% CI, 2.59\u201334.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); the use of chemotherapy other than pemetrexed (aOR\u2009=\u20094.80, 95% CI, 1.05\u201321.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043); the presence of third\u2010space fluid (aOR\u2009=\u20093.58, 95% CI, 1.16\u201311.05,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027), pleural effusion (aOR\u2009=\u20094.20, 95% CI, 1.34\u201313.17,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) and pericardial effusion (aOR\u2009=\u20097.97, 95% CI, 1.18\u201353.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033). Number of lines of cytotoxic chemotherapy the patients received was the risk factor for pack cell transfusion with aOR of 2.35 (95% CI, 1.54\u20133.60,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hematological toxicities were commonly seen in the treatment course of mesothelioma. Risk factors include disease factors and treatment factors. Use of ICI could bring about hope in reducing the risk of hematological toxicities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70243","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:41:39Z","timestamp":1768826499000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Factors of Hematological Toxicity of Mesothelioma Treatment\u2014A Territory\u2010Wide Retrospective Study"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5611-1637","authenticated-orcid":false,"given":"Wang Chun","family":"Kwok","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine Queen Mary Hospital, University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8179-8293","authenticated-orcid":false,"given":"Desmond Yat Hin","family":"Yap","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Queen Mary Hospital, The University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac Sze Him","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Statistics The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4499-5284","authenticated-orcid":false,"given":"James Chung Man","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine Queen Mary Hospital, University of Hong Kong  Hong Kong SAR 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