{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:09:35Z","timestamp":1777392575649,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>CT\u2010guided transthoracic needle biopsy (CT\u2010TTNB) is an essential diagnostic procedure but is associated with complications such as pneumothorax and pulmonary hemorrhage. The distance from the lesion to the pleura (traversed parenchymal distance) is widely recognized as a major risk factor. This study aims to evaluate the correlation between the traversed lung parenchymal distance and post\u2010CT\u2010TTNB complications, and to identify independent predictors for these complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cross\u2010sectional study was conducted on 226 patients who underwent CT\u2010TTNB. Data on demographics, lesion characteristics, and procedure\u2010related factors (traversed parenchymal distance, number of biopsy samples) were collected. Multivariable logistic regression analysis was used to identify independent predictors for pneumothorax and pulmonary hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall complication rate was 47.35%, with pneumothorax at 29.2% and pulmonary hemorrhage at 32.74%. Multivariable analysis showed that statistically significant independent predictors for pneumothorax were male gender (adjusted odds ratio [aOR]\u2009=\u20093.78; 95% confidence interval [CI]: 1.81\u20137.89;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and the number of biopsy samples (aOR\u2009=\u20090.65; 95% CI: 0.45\u20130.94;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022). The traversed lung parenchymal distance was not a statistically significant independent predictor for either pneumothorax (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.251) or pulmonary hemorrhage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study population, male gender and the number of biopsy samples were significantly associated with the risk of pneumothorax. The traversed lung parenchymal distance did not emerge as an independent predictor in the multivariable model. These findings challenge the traditional view and emphasize the need for a multifactorial risk assessment model rather than relying on a single parameter.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70286","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:28:47Z","timestamp":1777285727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation Between Distance From Lesions to Pleura and Complications in\n                    <scp>CT<\/scp>\n                    \u2010Guided Lung Biopsy: A Cross\u2010Sectional Study in Vietnam"],"prefix":"10.1111","volume":"17","author":[{"given":"Thanh Dinh","family":"Le","sequence":"first","affiliation":[{"name":"Thong Nhat Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6437-918X","authenticated-orcid":false,"given":"Thuan Nguyen","family":"Huynh","sequence":"additional","affiliation":[{"name":"Thong Nhat Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanh Chi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Thong Nhat Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hau Thi","family":"Tran","sequence":"additional","affiliation":[{"name":"Thong Nhat Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Vo Cong","family":"Do","sequence":"additional","affiliation":[{"name":"Thong Nhat Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khang Quang","family":"Le","sequence":"additional","affiliation":[{"name":"Thong Nhat Hospital  Ho Chi Minh City Vietnam"},{"name":"University of Medicine and Pharmacy  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Son Thai","family":"Tran","sequence":"additional","affiliation":[{"name":"Buon Ma Thuot Medical University Hospital  Buon Ma Thuot Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3511-9987","authenticated-orcid":false,"given":"Thanh Toan","family":"Vo","sequence":"additional","affiliation":[{"name":"Thong Nhat Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"issue":"4","key":"e_1_2_11_2_1","first-page":"228","article-title":"Assessing Risk Factors for Complications in Computer Tomography\u2010Guided Lung Biopsy: Quantitative Analysis for Predicting Pneumothorax","volume":"44","author":"Zhang J.","year":"2024","journal-title":"Annals of Saudi Medicine"},{"issue":"6","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"W678","DOI":"10.2214\/AJR.10.4659","article-title":"Complications of CT\u2010Guided Percutaneous Needle Biopsy of the Chest: Prevention and Management","volume":"196","author":"Wu C. C.","year":"2011","journal-title":"American Journal of Roentgenology"},{"issue":"5","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.21037\/qims-19-1024","article-title":"Risk Factors Associated With Pulmonary Hemorrhage and Hemoptysis Following Percutaneous CT\u2010Guided Transthoracic Lung Core Needle Biopsy: A Retrospective Study of 1,090 Cases","volume":"10","author":"Zhu J.","year":"2020","journal-title":"Quantitative Imaging in Medicine and Surgery"},{"issue":"1","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s00330-016-4357-8","article-title":"Complication Rates of CT\u2010Guided Transthoracic Lung Biopsy: Meta\u2010Analysis","volume":"27","author":"Heerink W. J.","year":"2017","journal-title":"European Radiology"},{"issue":"3","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2214\/AJR.09.3224","article-title":"Incidence of and Risk Factors for Pneumothorax and Chest Tube Placement After CT Fluoroscopy\u2013Guided Percutaneous Lung Biopsy: Retrospective Analysis of the Procedures Conducted Over a 9\u2010Year Period","volume":"194","author":"Hiraki T.","year":"2010","journal-title":"American Journal of Roentgenology"},{"key":"e_1_2_11_7_1","unstructured":"World Health Organization WHO Global Report on Trends in Prevalence of Tobacco Use 2000\u20132024 and Projections 2025\u20132030 Report No.: 978\u201092\u20104\u2010008826\u20109 (World Health Organization 2024)."},{"issue":"3","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"205846012513264","DOI":"10.1177\/20584601251326485","article-title":"Diagnostic Yield and Complications of CT\u2010Guided Biopsy of Lung Lesions as a Radiological Outpatient Clinic Procedure","volume":"14","author":"Johansen K. B.","year":"2025","journal-title":"Acta Radiologica Open"},{"issue":"4","key":"e_1_2_11_9_1","article-title":"Assessment of Independent Risk Factors of Developing Pneumothorax During Percutaneous Core Needle Lung Biopsy: Focus on Lesion Depth","volume":"13","author":"Lee H.\u2010Y.","year":"2016","journal-title":"Iranian Journal of Radiology"},{"issue":"2","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1148\/radiology.218.2.r01fe33491","article-title":"Factors Influencing Pneumothorax Rate at Lung Biopsy: Are Dwell Time and Angle of Pleural Puncture Contributing Factors?","volume":"218","author":"Ko J. P.","year":"2001","journal-title":"Radiology"},{"issue":"2","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.232168","article-title":"CT\u2010Guided Coaxial Lung Biopsy: Number of Cores and Association With Complications","volume":"313","author":"Kim C. R.","year":"2024","journal-title":"Radiology"},{"issue":"1","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/s12890-025-03872-x","article-title":"The Association Between Core Number and Complications in Ultrasound\u2010Guided Percutaneous Lung Core Needle Biopsy for Subpleural Primary Lung Cancer: A Retrospective Study","volume":"25","author":"Shen M.","year":"2026","journal-title":"BMC Pulmonary Medicine"},{"issue":"4","key":"e_1_2_11_13_1","doi-asserted-by":"crossref","DOI":"10.2217\/lmt-2020-0022","article-title":"Biopsy Frequency and Complications Among Lung Cancer Patients in the United States","volume":"9","author":"Zhang Y.","year":"2020","journal-title":"Lung Cancer Management"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.70286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.70286","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.70286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:57:17Z","timestamp":1777370237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.70286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/1759-7714.70286"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.70286","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2026-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70286"}}