{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:17:39Z","timestamp":1778807859753,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3603800"],"award-info":[{"award-number":["2023YFC3603800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3603801"],"award-info":[{"award-number":["2023YFC3603801"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Optimizing perioperative management strategies to promote the rapid recovery remains a focus and challenge research. Normobaric hyperoxia enhances antioxidant defenses and promotes tissue repair, improving functional outcomes in stroke patients. This study aimed to investigate the influence of perioperative normobaric hyperoxia combined with pulmonary rehabilitation on video\u2010assisted thoracoscopic surgery\u2010treated lung cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This trial enrolled 100 patients with pulmonary nodules scheduled for video\u2010assisted thoracoscopic surgery (VATS). Eligible patients were randomized in a 1:1 ratio into two groups. The primary outcomes were postoperative length of stay (LOS) and total hospitalization costs. Secondary outcomes included incidence of postoperative pulmonary complications (PPCs), postoperative inflammatory indicators, activities of daily living (ADL), perioperative outcomes, and readmission rates within 30\u2009days and 6\u2009months after discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighty\u2010four patients completed the study. The intervention group experienced a significantly shorter postoperative LOS (2\u2009days, IQR 1.8 to 3) and lower total hospitalization cost (41\u2009185 RMB, IQR 35094 to 47\u2009028). The intervention group reported better scores of ADL on postoperative (45 points, IQR 33.8 to 55) and discharge (95 points, IQR 90 to 100). But there were no differences in the incidence of PPCs, C\u2010reactive protein, procalcitonin, perioperative outcomes, and readmission rates within 30\u2009days and 6\u2009months after discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Normobaric hyperoxia combined with perioperative pulmonary rehabilitation may reduce postoperative LOS and decreased costs for VATS\u2010treated lung cancer patients. This approach expected to optimize outcomes and improve rehabilitation for early\u2010stage lung cancer patients.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      The clinical trial was registered on January 17, 2018, with the registration number ChiCTR1800014512\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70301","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:23:53Z","timestamp":1778639033000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Normobaric Hyperoxia Combined With Pulmonary Rehabilitation Intervention for Enhanced Short\u2010Term Recovery in Lung Cancer Surgery"],"prefix":"10.1111","volume":"17","author":[{"given":"Mei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiani","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"West China School of Nursing Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"West China School of Nursing Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6253-0284","authenticated-orcid":false,"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihui","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guosheng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"West China School of Nursing Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"West China School of Nursing Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Lung Cancer Center\/Lung Cancer Institute, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutian","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Lung Cancer Center\/Lung Cancer Institute, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9446-0707","authenticated-orcid":false,"given":"Jingsi","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Lung Cancer Center\/Lung Cancer Institute, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0541-905X","authenticated-orcid":false,"given":"Quan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3427-5937","authenticated-orcid":false,"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"issue":"9","key":"e_1_2_14_3_1","first-page":"805","article-title":"Chinese Medical Association Guideline for Clinical Diagnosis and Treatment of Lung Cancer (2024 Edition)","volume":"46","author":"Oncology Society of Chinese Medical A","year":"2024","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.11.055"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2019.08.057"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15848"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22517"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70228-0"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.14696"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2012.08.206"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt375"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10060958"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.07.004"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02985-6"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02809-5"},{"issue":"8","key":"e_1_2_14_16_1","first-page":"716","article-title":"Chinese Expert Consensus on Diagnosis and Treatment of Pulmonary Nodules(2024)","volume":"47","author":"Chinese Thoracic Society CMA, Chinese Alliance Against Lung Cancer Expert G","year":"2024","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000118"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-017-0409-2"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.09.112"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199908000-00016"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2020.11.023"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2022.02.025"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.21037\/jovs.2017.12.17"},{"issue":"7","key":"e_1_2_14_24_1","article-title":"Evaluation of Prognostic Risk Models for Postoperative Pulmonary Complications in Adult Patients Undergoing Major Abdominal Surgery: A Systematic Review and International External Validation Cohort Study","volume":"4","author":"Collaborative ST, Collaborative T","year":"2022","journal-title":"Lancet Digital Health"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e32821"},{"issue":"7","key":"e_1_2_14_26_1","article-title":"A Prognostic Model for Use Before Elective Surgery to Estimate the Risk of Postoperative Pulmonary Complications (GSU\u2010Pulmonary Score): A Development and Validation Study in Three International Cohorts","volume":"6","author":"Surgery NGHRUoG, Collaborative ST","year":"2024","journal-title":"Lancet Digital Health"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1265204"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m540"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/85.1.109"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.2.201"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010458"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2011-0144OC"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2011.10.012"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3534"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.07.025"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11624"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-023-02259-1"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215507077286"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivx141"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.10.024"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.02.013"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000804"}],"container-title":["Thoracic Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.70301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1759-7714.70301","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1759-7714.70301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:02:23Z","timestamp":1778806943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1759-7714.70301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/1759-7714.70301"],"URL":"https:\/\/doi.org\/10.1111\/1759-7714.70301","archive":["Portico"],"relation":{},"ISSN":["1759-7706","1759-7714"],"issn-type":[{"value":"1759-7706","type":"print"},{"value":"1759-7714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70301"}}