{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:01:44Z","timestamp":1779962504367,"version":"3.53.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Segmentectomy has been recognized as non\u2010inferior to lobectomy for the treatment of small\u2010sized non\u2010small cell lung cancer (NSCLC). This study aimed to identify factors associated with the margin quality of segmentectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with small\u2010sized NSCLC (\u2264\u20092\u2009cm) who underwent segmentectomy between January 2019 and December 2023 were screened. A sufficient surgical margin was defined as \u2265 the maximum tumor diameter. Logistic regression analyses were performed to identify factors associated with insufficient margins following segmentectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 667 patients were included. Of them, sufficient surgical margins were achieved in 577 patients (86.5%). Compared to patients with sufficient margins, those with insufficient margins had larger tumor sizes, longer tumor\u2010to\u2010pleura distances, shorter tumor\u2010to\u2010segmental bronchus distances, and higher percentages of central tumors and intersegmental tumors. Multivariate logistic regression analysis revealed that tumor size (OR\u2009=\u20092.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), tumor\u2010to\u2010pleura distance (OR\u2009=\u20091.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045), tumor\u2010to\u2010segmental bronchus distance (OR\u2009=\u20090.76,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011), and tumor subsegmental attribution (intersegmental vs. intrasegmental tumors, OR\u2009=\u20092.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) were significantly associated with the margin quality of segmentectomy. The optimal cutoff values to stratify the risk of insufficient margins were 1.1\u2009cm for tumor size, 3.0\u2009cm for tumor\u2010to\u2010pleura distance, and 5.2\u2009cm for tumor\u2010to\u2010segmental bronchus distance, respectively. Notably, 98.9% (89\/90) of patients with insufficient margins exhibited at least one of these identified risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tumor size, tumor\u2010to\u2010pleura distance, tumor\u2010to\u2010segmental bronchus distance, and nodule subsegmental attribution might be correlated with insufficient margins during segmentectomy. Surgeons should exercise extra caution when performing segmentectomy for patients with tumors harboring multiple such high\u2010risk features.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70307","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:03:58Z","timestamp":1778835838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Margin Quality Analysis and Risk Factors Associated With Insufficient Margins Following Segmentectomy for Small\u2010Sized Non\u2010Small Cell Lung Cancer"],"prefix":"10.1111","volume":"17","author":[{"given":"Chen","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Jiangsu Province Hospital The First Affiliated Hospital With Nanjing Medical University  Nanjing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7941-8623","authenticated-orcid":false,"given":"Yanhu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Jiangsu Province Hospital The First Affiliated Hospital With Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Jiangsu Province Hospital The First Affiliated Hospital With Nanjing Medical University  Nanjing 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