{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:03:45Z","timestamp":1784027025843,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Metastatic involvement of the appendix from a primary distant tumor is uncommon, and the same holds true for tumors originating in the lungs. Consequently, data on pathogenesis, diagnostic approaches, therapeutic strategies, and outcomes of lung\u2010to\u2010appendix metastasis remain scarce. Here we describe two patients managed at our institution between September 2018 and August 2025 and integrate their data with 30 cases identified through a structured literature search, yielding an analytical cohort of 32 individuals. The cohort comprised 26 males and 6 females, with a median age at detection of appendiceal involvement of 63.5\u2009years (range, 41\u201385\u2009years). The median interval from primary lung\u2010cancer diagnosis was 12\u2009months (range, 1\u201354\u2009months). Histotypes were small\u2010cell carcinoma (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200915), adenocarcinoma (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200914), squamous\u2010cell carcinoma (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091) and not otherwise specified (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092). At the time of appendiceal disease, 20 patients (62.5%) already harbored concurrent extra\u2010appendiceal metastases. Surgical intervention was undertaken in 31 cases; appendectomy\u2014performed open or laparoscopically\u2014was the procedure of choice in 26 (83.9%). In summary, the appendix may serve as an unusual but clinically relevant sanctuary site in patients with advanced lung cancer, particularly those with small\u2010cell or adenocarcinomatous histology. Systematic staging, tailored surgical resection, and individualized systemic therapy are essential to prolong survival and preserve quality of life.\n                  <\/jats:p>","DOI":"10.1111\/1759-7714.70318","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:41:44Z","timestamp":1782920504000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Manifestations and Outcomes of Lung Cancer Patients With Appendiceal Metastasis"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-7484","authenticated-orcid":false,"given":"Kangjian","family":"Cui","sequence":"first","affiliation":[{"name":"Department of General Surgery Chongqing Traditional Chinese Medicine Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pathology Chongqing Traditional Chinese Medicine Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Chongqing Traditional Chinese Medicine Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Chongqing Traditional Chinese Medicine Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.7822"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029\u2010023\u201000986\u20105"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(05)80446\u20105"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(62)91844\u20105"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02617258"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198811000-00033"},{"issue":"3","key":"e_1_2_10_9_1","first-page":"319","article-title":"Metastasis From Adenocarcinoma of the Lung Producing Acute Appendicitis","volume":"85","author":"HAID","year":"1992","journal-title":"American Journal of Gastroenterology"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101827.1996.tb03601.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1999.18.1.23"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480407000810"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1385\/IJGC:36:1:059"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318162336b"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e328343c9bf"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3182336222"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2011.6.6826"},{"key":"e_1_2_10_18_1","unstructured":"H.NabiandD.Kozman \u201cAcute Appendicitis Secondary to Metastasis From Previously Undiagnosed Small Cell Lung Carcinoma \u201d2014."},{"issue":"1","key":"e_1_2_10_19_1","first-page":"55","article-title":"Metastasis to the Appendix From Lung Adenocarcinoma Manifesting as Acute Appendicitis: A Case Report","volume":"30","author":"Su Y. 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