{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:47:44Z","timestamp":1792054064811,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The optimal surgical strategy for early\u2010stage lung adenocarcinoma appearing as part\u2010solid nodules (PSN) versus pure solid nodules (SPN) remains debated. This study directly compares their clinicopathological features, surgical outcomes, and recurrence patterns to inform personalized management based on CT characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analyzed 710 surgical patients with clinical stage IA lung adenocarcinoma. Nodules were categorized as PSN or SPN by the presence of a GGO component on preoperative CT. Interaction\u2010effect analysis assessed CT\u2010attenuation dynamics in solid components. Propensity\u2010score matching balanced intergroup confounders, and Cox regression identified recurrence risk factors for each type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean CT\u2010solid value (\u221213.2 Hu vs. 22.2 Hu,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and the trend of change in CT\u2010solid value during follow\u2010up (Interaction effect Index: \u22120.011078,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were significantly different between PSN and SPN. Upon histological examination, PSN had significantly lower incidences of visceral pleural invasion (11.7% vs. 30.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and lymph node metastasis (11.2% vs. 20.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) than SPN. After propensity\u2010score matching, patients with PSN had significantly better recurrence\u2010free survival (86.8% vs. 70.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) than those with SPN. In Cox regression analysis, sublobar resection and lymph node sampling\u2010only were associated with increased risk of loco\u2010regional recurrence in SPN, but not in PSN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PSN and SPN show distinct clinicopathological features and prognostic profiles, suggesting potentially different biological behaviors. CT features need to be incorporated with clinical tumor stage in deciding surgical strategies on resection extent and lymph node examination for early\u2010stage lung adenocarcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70330","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:47:04Z","timestamp":1782208024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological and Prognostic Disparities in Part\u2010Solid Versus Pure Solid Pulmonary Nodules as Early\u2010Stage Lung Adenocarcinoma"],"prefix":"10.1111","volume":"17","author":[{"given":"Hanyue","family":"Li","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runhua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhitao","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-9975","authenticated-orcid":false,"given":"Wentao","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Thoracic Surgery Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214726"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.03.025"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2204.0023"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(23)00041-3"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2023.01.019"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2019.03.090"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02333-3"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212083"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.08.008"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2025.06.007"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-25-00610"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2462070712"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017162894"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318206a221"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.06.001"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezv249"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.01.060"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016142975"},{"key":"e_1_2_12_20_1","first-page":"74","article-title":"Correlation Between the Size of the Solid Component on Thin\u2010Section CT and the Invasive Component on Pathology in Small Lung Adenocarcinomas Manifesting as Ground\u2010Glass Nodules","volume":"1","author":"Lee K. 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