{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:03:47Z","timestamp":1784027027971,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The 1\u2010year pulmonary functional impact of resecting additional ipsilateral ground\u2010glass opacities (GGOs) during unilateral surgery remains uncertain. We evaluated whether resection of multiple ipsilateral GGOs is associated with less favorable postoperative pulmonary function preservation than resection of a single lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed patients with at least two ipsilateral GGOs who underwent pulmonary surgery between January 2020 and December 2024. Patients were grouped according to whether 1 lesion or \u2265\u20092 lesions were resected during the index operation. The primary outcomes were 1\u2010year retention of FVC, FEV1, and DLCOc\u2010SB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 291 patients were included; 146 underwent resection of 1 lesion and 145 underwent resection of \u2265\u20092 lesions. After propensity score matching, 232 patients remained (116 per group). In the matched cohort, absolute postoperative FVC, FEV1, and DLCOc\u2010SB at 1\u2009year were similar between groups. However, resection of \u2265\u20092 lesions was associated with greater declines and lower retention of FVC (90.41% vs. 94.55%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), FEV1 (87.10% vs. 93.73%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and DLCOc\u2010SB (91.04% vs. 93.70%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016). In multivariable analyses, resection of \u2265\u20092 lesions remained independently associated with lower FEV1, FVC, and DLCOc\u2010SB retention. Operative time was longer in the \u2265\u20092\u2010lesion group, whereas other perioperative outcomes were similar.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among surgically fit patients with multiple ipsilateral GGOs, resection of \u2265\u20092 lesions was associated with less favorable pulmonary function preservation than resection of a single lesion, suggesting a functional trade\u2010off when considering resection of additional ipsilateral lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70344","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:00:09Z","timestamp":1783069209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary Functional Impact of Resecting Additional Ipsilateral Ground\u2010Glass Opacities: A Retrospective Propensity Score\u2013Matched Study"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5601-5745","authenticated-orcid":false,"given":"Jia","family":"Han","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaojuan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqiang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911793"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.24287"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.06.058"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-020-00363-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezad222"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2025.09.011"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezaf130"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06533-w"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109332"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201310-1863PP"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.0345-2020"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.01.002"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx357"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2019.05.052"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034905"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201112-2160CI"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212083"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.09.146"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.04.03"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-024-15550-z"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/resp.70183"}],"container-title":["Thoracic 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