{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:06:13Z","timestamp":1789455973004,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2022IL0003"],"award-info":[{"award-number":["2022IL0003"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study evaluated the validity of the constant\u2010load cycle endurance test (CET), performed at 75% of maximal power output, in patients with lung cancer undergoing radiation therapy. Its feasibility, responsiveness to pulmonary rehabilitation (PR), and clinical applicability were also examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010three patients participated in a 4\u2010week PR program during radiation therapy. CET time was compared with the 6\u2010min walk test (6MWT) to assess concurrent validity. Patients were stratified by 6MWT distance (\u2265\u2009450\u2009m\u2009=\u2009active; &lt;\u2009450\u2009m\u2009=\u2009inactive). CET, 6MWT, knee extensor strength, and handgrip strength were measured at baseline and post\u2010PR. Adverse events were monitored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CET time showed a moderate correlation with 6MWT distance (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.57,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The correlation was stronger in the active subgroup (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) but not significant in the inactive subgroup (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.09,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.63). After PR, significant improvements were observed in CET, knee extensor (left) strength (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Subgroup analysis indicated that inactive patients primarily improved in 6MWT, whereas active patients showed greater gains in CET. No adverse events occurred during testing or PR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CET demonstrated moderate validity with the 6MWT and was responsive to PR, particularly in patients with higher functional capacity. CET appears feasible, safe, and complementary to walk tests, potentially capturing improvements masked by ceiling effects. Larger studies are needed to confirm its role as a standard outcome measure in PR for lung cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70349","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:07:41Z","timestamp":1787742461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Validity and Feasibility of the Constant\u2010Load Cycle Endurance Test in Lung Cancer Patients Undergoing Radiation Therapy"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9089-2086","authenticated-orcid":false,"given":"Junghwa","family":"Do","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine Team Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungeun","family":"Park","sequence":"additional","affiliation":[{"name":"Rehabilitation Research Center, Biomedical Engineering Research Center Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Critical Care Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Team Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Rehabilitation Research Center, Biomedical Engineering Research Center Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hak","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwayeong","family":"Cheon","sequence":"additional","affiliation":[{"name":"Rehabilitation Research Center, Biomedical Engineering Research Center Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1534-7931","authenticated-orcid":false,"given":"Jae Yong","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735416645180"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.03.010"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-020-01273-0"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-016-1068-7"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13041"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.07.006"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70195-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00150314"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.10.009"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.12.039"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2025.108546"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2005.03.003"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjdh\/ztab036"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.5543\/tkda.2023.52279"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00664-2021"},{"key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/00008483-200303000-00012","article-title":"Constant\u2010Load Cycle Endurance Performance: Test\u2010Retest Reliability and Validity in Patients With COPD","volume":"23","author":"van 't Hul A.","year":"2003","journal-title":"Journal of Cardiopulmonary Rehabilitation"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465818755091"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-97"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202305-480OC"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.15326\/jcopdf.2022.0331"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0760277"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2008.01.020"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.5.9804004"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31827c0b94"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/s25102981"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193412449804"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002864"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivy258"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphys.2022.03.001"},{"key":"e_1_2_12_32_1","article-title":"The Thirty\u2010Second Sit\u2010To\u2010Stand Test as a Predictor of Postoperative Complications of Lung Resection: A Real\u2010World Study","volume":"51","author":"Pedro I. 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