{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:33Z","timestamp":1787013753494,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82503629"],"award-info":[{"award-number":["82503629"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Immune checkpoint inhibitors (ICIs), such as PD\u20101\/PD\u2010L1 inhibitors, have revolutionized the treatment of extensive\u2010stage small\u2010cell lung cancer (ES\u2010SCLC). Chemotherapy combined with PD\u20101 or PD\u2010L1 inhibitors has become the standard first\u2010line treatment for ES\u2010SCLC. However, with the broad application of immunotherapy, adverse events associated with this therapy have been increasingly reported by clinicians. The identification of atypical and specific manifestations of immune\u2010related adverse events (irAEs) requires accumulated experience on the part of clinicians. In this article, we report the case of a patient over 50\u2009years of age who was initially diagnosed with ES\u2010SCLC. Clinical symptoms mainly manifested as allodynia of the abdominal wall following PD\u2010L1 inhibition immunotherapy. This symptom progressed with continued immunotherapy and resolved after cessation of immunization and treatment with prednisone. A peripheral neuropathy antibody test revealed anti\u2010GM4 IgG antibody positivity. On the basis of the patient's clinical manifestations and medication history described above, a diagnosis of immune\u2010related peripheral neuropathy was made. In this case, the irAE severely hindered the treatment process and impaired the patient's quality of life. Through this case report and a review of the literature, we aim to explore how to timely and accurately identify irAEs in immunotherapy, especially nonspecific irAEs, and provide timely treatment to improve patient quality of life and survival and immunotherapy precision and safety.<\/jats:p>","DOI":"10.1111\/1759-7714.70368","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T02:12:25Z","timestamp":1785118345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Rare Peripheral Neuropathy With Abdominal Wall Allodynia in Extensive\u2010Stage Small\u2010Cell Lung Cancer Treated Using Durvalumab"],"prefix":"10.1111","volume":"17","author":[{"given":"Ruidan","family":"Li","sequence":"first","affiliation":[{"name":"Respiratory and Critical Care Medicine Department Norinco General Hospital  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9705-5265","authenticated-orcid":false,"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"West China School of Medicine, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1241-1595","authenticated-orcid":false,"given":"Xiaoqian","family":"Zhai","sequence":"additional","affiliation":[{"name":"Lung Cancer Center\/Lung Cancer Institute, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4994-2317","authenticated-orcid":false,"given":"Jie","family":"Shao","sequence":"additional","affiliation":[{"name":"Respiratory and Critical Care Medicine Department Norinco General Hospital  Xi'an Shaanxi 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