{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:23:50Z","timestamp":1787729030173,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study examined whether lobar\u2010specific dose\u2010volume histogram (DVH) parameters add predictive information for radiation pneumonitis (RP) beyond conventional whole\u2010lung parameters in patients with non\u2010small cell lung cancer (NSCLC) undergoing definitive radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 145 NSCLC patients treated between 2018 and 2023. Conventional whole\u2010lung parameters, including V5%, V20%, and mean lung dose (MLD), lobar\u2010specific parameters, including Low V20% (percentage of the bilateral lower lobes receiving \u2265\u200920\u2009Gy), and clinical parameters were analyzed. The predictive performance of each parameter for Grade \u2265\u20092 RP was evaluated using receiver operating characteristic curve analysis. Associations with Grade \u2265\u20092 RP were assessed by Gray test and Fine\u2010Gray competing risks regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Grade \u2265\u20092 RP had an incidence of 41% (60\/145) and showed significant associations with V20% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), MLD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025), Low V5% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), and Low V20% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). In multivariate analysis, a high Brinkman Index (BI) (HR\u2009=\u20092.10, 95% CI: 1.27\u20133.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) and high Low V20% (HR\u2009=\u20092.31, 95% CI: 1.12\u20134.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023) were independent predictors for Grade \u2265\u20092 RP. The correlation between V20% and Low V20% was moderate (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.505), with minimal multicollinearity (variance inflation factor 1.34).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low V20% was independently associated with Grade \u2265\u20092 RP and may provide complementary information to conventional whole\u2010lung DVH parameters and BI. This simple lobar\u2010specific parameter may help refine pretreatment RP risk stratification, although external validation is required before its incorporation into individualized planning constraints.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70369","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T09:30:35Z","timestamp":1787131835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation Between Lower Lobe Dose Parameters and Radiation Pneumonitis in Definitive Radiation Therapy for Non\u2010Small Cell Lung Cancer"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5279-2431","authenticated-orcid":false,"given":"Sachiko","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Nara Medical University  Kashihara Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhide","family":"Wakai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Nara Medical University  Kashihara Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeto","family":"Hontsu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nara Medical University  Kashihara Nara Japan"},{"name":"Department of Thoracic Oncology Kansai Medical University Medical Center  Moriguchi Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahide","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nara Medical University  Kashihara Nara Japan"},{"name":"Department of Cancer Genomics and Medical Oncology Nara Medical University  Kashihara Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-4494","authenticated-orcid":false,"given":"Kaori","family":"Yamaki","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Nara Medical University  Kashihara Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Tamamoto","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Nara Medical University  Kashihara Nara Japan"},{"name":"Department of Strategic Promotion of Medical Information Cooperation Nara Medical University  Kashihara Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Cancer Genomics and Medical Oncology Nara Medical University  Kashihara Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6342-4693","authenticated-orcid":false,"given":"Fumiaki","family":"Isohashi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Nara Medical University  Kashihara Nara 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