{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T08:29:12Z","timestamp":1786609752545,"version":"build-2736575974"},"reference-count":8,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>MET exon 14 skipping is an actionable oncogenic driver in non\u2013small cell lung carcinoma (NSCLC); however, noncanonical splice\u2010region variants are frequently classified as variants of unknown significance (VUS), which may result in missed therapeutic opportunities and highlight limitations in current DNA next\u2010generation sequencing (NGS) reporting criteria. We report a patient with pulmonary sarcomatoid carcinoma harboring a noncanonical MET splice donor\u2013proximal indel (c.3022_3028\u2009+\u200913delinsA), initially interpreted as a VUS, who achieved a rapid and durable response to capmatinib. Subsequent RNA sequencing and droplet digital PCR (ddPCR) confirmed MET exon 14 skipping, supporting the value of orthogonal transcript\u2010level validation for exon\u2010adjacent variants.<\/jats:p>","DOI":"10.1111\/1759-7714.70371","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T03:10:51Z","timestamp":1786158651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Noncanonical\n                    <scp>MET<\/scp>\n                    Exon 14 Splice\u2010Site Variant in Pulmonary Sarcomatoid Carcinoma With Response to Capmatinib"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9420-9096","authenticated-orcid":false,"given":"Hyung\u2010Joo","family":"Oh","sequence":"first","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"},{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo\u2010Duk","family":"Choi","sequence":"additional","affiliation":[{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Gwangju South Korea"},{"name":"Department of Pathology Chonnam National University Medical School  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5788-5140","authenticated-orcid":false,"given":"Yoon\u2010La","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Translational Genomics Samsung Medical Center, Sungkyungwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha\u2010Young","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"},{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon\u2010Young","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"},{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang\u2010Hyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"},{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0039-0662","authenticated-orcid":false,"given":"Jung\u2010Hwan","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"},{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8701-0786","authenticated-orcid":false,"given":"Cheol\u2010Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"},{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4837-1321","authenticated-orcid":false,"given":"In\u2010Jae","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"},{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7019-7687","authenticated-orcid":false,"given":"Young\u2010Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine Chonnam National University Medical School  Gwangju South Korea"},{"name":"Lung Cancer Center Chonnam National University Hwasun Hospital  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"PO.20.00516","article-title":"MET Exon 14 Skipping Mutations in Non\u2010Small\u2010Cell Lung Cancer: An Overview of Biology, Clinical Outcomes, and Testing Considerations","volume":"5","author":"Socinski M. 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