{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:23:20Z","timestamp":1787729000549,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osimertinib is standard therapy for EGFR\u2010mutant lung cancer, and HER2 amplification is a known resistance mechanism. We report HER2\u2010positive breast cancer showing durable regression during osimertinib monotherapy for synchronous EGFR\u2010mutated lung adenocarcinoma. Post\u2010treatment analysis showed marked regression, HER2 amplification, no detectable EGFR, HER2, or PIK3CA mutations, ER\/PgR negativity, preserved PTEN, and reduced proliferative activity. These findings suggest ERBB pathway inhibition may have contributed, although the mechanism remains speculative without functional validation. This hypothesis\u2010generating observation describes unexpected breast cancer regression during osimertinib treatment.<\/jats:p>","DOI":"10.1111\/1759-7714.70379","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T05:55:47Z","timestamp":1786773347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exceptional Response of\n                    <scp>HER2<\/scp>\n                    \u2010Positive Breast Cancer to Osimertinib: A Case Report"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6036-2486","authenticated-orcid":false,"given":"Hirotoshi","family":"Yasui","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Toyohashi Municipal Hospital  Toyohashi Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misaki","family":"Hatasa","sequence":"additional","affiliation":[{"name":"Department of 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