{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:06:35Z","timestamp":1789455995731,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Ground\u2010glass opacities (GGOs) are increasingly detected due to widespread low\u2010dose CT screening for lung cancer. Among them, malignant GGOs (mGGOs) are a clinical challenge. This study aimed to compare the radiological and anatomopathological characteristics of pure and semi\u2010solid mGGOs and to identify radiological predictive factors for consolidation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted on patients resected due to mGGOs between 2016 and 2023. Patients were classified based on whether initially pure mGGOs remained pure or developed a solid component before surgery. Radiological, pathological, and molecular characteristics were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 135 patients, 61 (46%) mGGOs became partially solid during surveillance. Semi\u2010solid mGGOs had a higher acinar component (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038) and larger pathological diameter (20 vs. 18\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047), while pure mGGOs had a higher lepidic percentage (20% vs. 10%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026). STAS and LVI were observed in 25% and 15% of cases. Logistic regression showed pleural contact was protective against consolidation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033), while arterial vascularization was predictive of consolidation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). Five\u2010year survival was comparable and satisfactory for both groups (81.7% for pures and 85.5% for semi\u2010solids). Overall, LVI but no STAS was cause of a lower survival expectancy in the entire sample, regardless of consolidation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both pure and semi\u2010solid mGGOs showed precocious pathological and molecular features. Surgical intervention with curative intent, even in pure GGOs, is accompanied by long expected survivals. Vascular features on imaging may help inform surgical decision\u2010making, whereas pathological LVI may have prognostic significance in patients with mGGOs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70384","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:30:02Z","timestamp":1787923802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decoding Malignant Lung Ground Glass Opacities: A Radiologic\u2013Pathologic Study From Pure to Semi\u2010Solid Lesions"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9422-0597","authenticated-orcid":false,"given":"Alessandro","family":"Bonis","sequence":"first","affiliation":[{"name":"Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health\u2014DCTV University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9006-4684","authenticated-orcid":false,"given":"Giulia","family":"Pagliarini","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health\u2014DCTV University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7239-1248","authenticated-orcid":false,"given":"Vincenzo","family":"Verzeletti","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health\u2014DCTV University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Cecchinato","sequence":"additional","affiliation":[{"name":"Unit of Advanced Clinical and Translational Imaging, Department of Cardiac, Thoracic, Vascular Sciences and Public Health\u2014DCTV University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Michielin","sequence":"additional","affiliation":[{"name":"Unit of Advanced Clinical and Translational Imaging, Department of Cardiac, Thoracic, Vascular Sciences and Public Health\u2014DCTV University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1020-6862","authenticated-orcid":false,"given":"Serena","family":"Zanardo","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health\u2014DCTV University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6041-8046","authenticated-orcid":false,"given":"Marco","family":"De Silvestro","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health\u2014DCTV University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4687-2369","authenticated-orcid":false,"given":"Luigi","family":"Lione","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health\u2014DCTV University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0924-5883","authenticated-orcid":false,"given":"Chiara","family":"Giraudo","sequence":"additional","affiliation":[{"name":"Unit of Advanced Clinical and Translational Imaging, Department of Cardiac, Thoracic, Vascular Sciences and Public Health\u2014DCTV University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Faccioli","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health\u2014DCTV University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Cannone","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health\u2014DCTV University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0885-2403","authenticated-orcid":false,"given":"Marco","family":"Mammana","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health\u2014DCTV University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6493-7413","authenticated-orcid":false,"given":"Alessandro","family":"Rebusso","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Department of Cardiac, Thoracic, 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