{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:06:19Z","timestamp":1789455979485,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2407303"],"award-info":[{"award-number":["2022YFC2407303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2025C01136"],"award-info":[{"award-number":["2025C01136"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Frozen section (FS) is the most widely used method to assess resected pulmonary lesions intraoperatively, although it also prolongs the operation time. We aimed to evaluate the accuracy of intraoperative rapid on\u2010site evaluation (ROSE) and evaluate whether it can serve as a faster auxiliary judgment alongside FS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective study was conducted on patients undergoing complete resection. Rapid Romanowsky (DiffQuik) staining was used for ROSE. The results of intraoperative ROSE were compared with those of frozen section and final pathological diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 75 patients were enrolled in the study, and 81 samples were taken for ROSE, which could assess biopsied samples within a few minutes. The time required for ROSE is significantly shorter than that for intraoperative frozen section analysis, and the mean time to diagnosis was significantly shorter for ROSE (by surgeon) than for FS (9.75\u2009min vs. 29.70\u2009min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The diagnostic accuracy of ROSE was 90.1% for surgeons, 95.6% for experienced pathologists, and 81.5% for junior pathologists, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ROSE can serve as an auxiliary judgment tool, enabling frozen sections to make intraoperative decisions more rapidly. It is a valuable technique for diagnosing lung tumor intraoperatively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1759-7714.70385","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:44:59Z","timestamp":1788583499000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intraoperative Rapid On\u2010Site Evaluation (\n                    <scp>ROSE<\/scp>\n                    ) vs. Frozen Section in Lung Surgery: A Prospective Study on Diagnostic Speed and Accuracy"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2272-2650","authenticated-orcid":false,"given":"Honghai","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6449-4439","authenticated-orcid":false,"given":"Qiuming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nursing, the First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihan","family":"You","sequence":"additional","affiliation":[{"name":"Department of Pathology, the First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pathology, the First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9494-9828","authenticated-orcid":false,"given":"Jian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou People's Republic of China"},{"name":"Zhejiang Key Laboratory of Clinical Evaluation Technology for Medical Device  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.08.1994"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(01)00354-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2021_696"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-1602-FSOLS"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.05.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181c09f9c"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2019.10.047"},{"issue":"7","key":"e_1_2_10_10_1","first-page":"7961","article-title":"Intraoperative Pathology Consultation for Pulmonary Lesions: Errors and Deferrals","volume":"8","author":"Akyildiz E. 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