{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:41:48Z","timestamp":1792456908176,"version":"4.5.0"},"reference-count":89,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF0723500"],"award-info":[{"award-number":["2023YFF0723500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["20230484314"],"award-info":[{"award-number":["20230484314"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Thoracic Cancer"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lung cancer remains the leading cause of cancer\u2010related mortality globally. Although low\u2010dose computed tomography (LDCT) is the current standard for early screening, its high false\u2010positive rates and cumulative radiation exposure create a pressing clinical need for complementary, non\u2010invasive diagnostic tools. Exhaled breath analysis represents an accessible strategy for early detection and risk stratification. Early breathomics primarily focused on gas\u2010phase volatile organic compounds (VOCs). However, as volatile metabolites, VOCs are chemically unstable and highly susceptible to background ambient air and physiological confounders. Distinct from gas\u2010phase analysis, exhaled breath condensate (EBC) offers enhanced biomarker stability and functions as a lung\u2010proximal liquid biopsy. By capturing non\u2010volatile, high\u2010molecular\u2010weight analytes, including tumor\u2010derived nucleic acids and proteins, EBC more closely reflects the underlying molecular mechanisms of the respiratory microenvironment. Nevertheless, the clinical translation of EBC remains constrained by severe sample dilution, unstandardized collection device architectures, and pre\u2010analytical inconsistencies. This review summarizes the progression from VOCs profiling to EBC\u2010based platforms, detailing recent advances in sample harvesting, ultrasensitive detection technologies, and multi\u2010omics integration. Advancing EBC toward routine clinical use requires consensus\u2010driven standard operating procedures and the application of machine learning algorithms to high\u2010dimensional datasets. Future efforts should prioritize large\u2010scale, multicenter prospective trials to validate specific EBC signatures, thereby establishing this technology as a reliable liquid biopsy for precision pulmonary oncology.<\/jats:p>","DOI":"10.1111\/1759-7714.70404","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:34:26Z","timestamp":1792456466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exhaled Breath Analysis for Lung Cancer Detection: From\n                    <scp>VOCs<\/scp>\n                    Signatures to\n                    <scp>EBC<\/scp>\n                    \u2010Based Liquid Biopsy and Clinical Translation"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6128-3757","authenticated-orcid":false,"given":"Penghai","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Peking University People's Hospital  Beijing China"},{"name":"Thoracic Oncology Institute Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenkai","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking University People's Hospital  Beijing China"},{"name":"Thoracic Oncology Institute Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaodong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking University People's Hospital  Beijing China"},{"name":"Thoracic Oncology Institute Peking University People's Hospital  Beijing China"},{"name":"Research Unit of Intelligence Diagnosis and Treatment in Early Non\u2010Small Cell Lung Cancer Chinese Academy of Medical Sciences, 2021RU002  Beijing China"},{"name":"Institute of Advanced Clinical Medicine Peking University  Beijing China"},{"name":"Frontiers Science Center for Cancer Integrative Omics Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking University People's Hospital  Beijing China"},{"name":"Thoracic Oncology Institute Peking University People's Hospital  Beijing China"},{"name":"Research Unit of Intelligence Diagnosis and Treatment in Early Non\u2010Small Cell Lung Cancer Chinese Academy of Medical Sciences, 2021RU002  Beijing China"},{"name":"Institute of Advanced Clinical Medicine Peking University  Beijing China"},{"name":"Frontiers Science Center for Cancer Integrative Omics Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0419-9139","authenticated-orcid":false,"given":"Mantang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking University People's Hospital  Beijing China"},{"name":"Thoracic Oncology Institute Peking University People's Hospital  Beijing China"},{"name":"Research Unit of Intelligence Diagnosis and Treatment in Early Non\u2010Small Cell Lung Cancer Chinese Academy of Medical Sciences, 2021RU002  Beijing China"},{"name":"Institute of Advanced Clinical Medicine Peking University  Beijing China"},{"name":"Frontiers Science Center for Cancer Integrative Omics Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung H.","year":"2021","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"10","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"7355","DOI":"10.3390\/curroncol29100578","article-title":"The Use of Breath Analysis in the Management of Lung Cancer: Is It Ready for Primetime?","volume":"29","author":"Keogh R. 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