{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:31:59Z","timestamp":1789979519030,"version":"4.0.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens Disease"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1111\/2049-632x.12181","type":"journal-article","created":{"date-parts":[[2014,4,19]],"date-time":"2014-04-19T07:57:26Z","timestamp":1397894246000},"page":"24-31","source":"Crossref","is-referenced-by-count":14,"title":["Growth, motility and resistance to oxidative stress of the melioidosis pathogen<i>Burkholderia pseudomallei<\/i>are enhanced by epinephrine"],"prefix":"10.1093","volume":"72","author":[{"given":"Narin","family":"Intarak","sequence":"first","affiliation":[{"name":"Department of Immunology; Faculty of Medicine Siriraj Hospital; Mahidol University; Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerachat","family":"Muangsombut","sequence":"additional","affiliation":[{"name":"Department of Immunology; Faculty of Medicine Siriraj Hospital; Mahidol University; Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paiboon","family":"Vattanaviboon","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology; Chulabhorn Research Institute; Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Stevens","sequence":"additional","affiliation":[{"name":"The Roslin Institute & Royal (Dick) School of Veterinary Studies; University of Edinburgh; Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunee","family":"Korbsrisate","sequence":"additional","affiliation":[{"name":"Department of Immunology; Faculty of Medicine Siriraj Hospital; Mahidol University; Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,5,12]]},"reference":[{"key":"10.1111\/2049-632X.12181-BIB0001|fim12181-cit-0001","doi-asserted-by":"crossref","first-page":"R120","DOI":"10.1186\/cc7972","article-title":"Pharmacokinetics of epinephrine in patients with septic shock: modelization and interaction with endogenous neurohormonal status","volume":"13","author":"Abboud","year":"2009","journal-title":"Crit Care"},{"key":"10.1111\/2049-632X.12181-BIB0002|fim12181-cit-0002","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1128\/JB.188.4.1551-1566.2006","article-title":"Genetic and transcriptional analysis of the siderophore malleobactin biosynthesis and transport genes in the human pathogen Burkholderia pseudomallei K96243","volume":"188","author":"Alice","year":"2006","journal-title":"J Bacteriol"},{"key":"10.1111\/2049-632X.12181-BIB0003|fim12181-cit-0003","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/00000658-200010000-00003","article-title":"Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa","volume":"232","author":"Alverdy","year":"2000","journal-title":"Ann Surg"},{"key":"10.1111\/2049-632X.12181-BIB0004|fim12181-cit-0004","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.1128\/JB.00266-06","article-title":"Superoxide dismutase B gene (sodB)-deficient mutants of Francisella tularensis demonstrate hypersensitivity to oxidative stress and attenuated virulence","volume":"188","author":"Bakshi","year":"2006","journal-title":"J Bacteriol"},{"key":"10.1111\/2049-632X.12181-BIB0005|fim12181-cit-0005","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1128\/IAI.00630-07","article-title":"Differential effects of epinephrine, norepinephrine, and indole on Escherichia coli O157:H7 chemotaxis, colonization, and gene expression","volume":"75","author":"Bansal","year":"2007","journal-title":"Infect Immun"},{"key":"10.1111\/2049-632X.12181-BIB0006|fim12181-cit-0006","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.micpath.2007.10.001","article-title":"The role of the QseC quorum-sensing sensor kinase in colonization and norepinephrine-enhanced motility of Salmonella enterica serovar Typhimurium","volume":"44","author":"Bearson","year":"2008","journal-title":"Microb Pathog"},{"key":"10.1111\/2049-632X.12181-BIB0007|fim12181-cit-0007","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1128\/IAI.71.4.1622-1629.2003","article-title":"Flagella are virulence determinants of Burkholderia pseudomallei","volume":"71","author":"Chua","year":"2003","journal-title":"Infect Immun"},{"key":"10.1111\/2049-632X.12181-BIB0008|fim12181-cit-0008","doi-asserted-by":"crossref","first-page":"10420","DOI":"10.1073\/pnas.0604343103","article-title":"The QseC sensor kinase: a bacterial adrenergic receptor","volume":"103","author":"Clarke","year":"2006","journal-title":"P Natl Acad Sci USA"},{"key":"10.1111\/2049-632X.12181-BIB0009|fim12181-cit-0009","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1136\/gut.2006.114926","article-title":"Norepinephrine increases the pathogenic potential of Campylobacter jejuni","volume":"56","author":"Cogan","year":"2007","journal-title":"Gut"},{"key":"10.1111\/2049-632X.12181-BIB0010|fim12181-cit-0010","doi-asserted-by":"crossref","first-page":"6091","DOI":"10.1128\/JB.182.21.6091-6098.2000","article-title":"The mammalian neuroendocrine hormone norepinephrine supplies iron for bacterial growth in the presence of transferrin or lactoferrin","volume":"182","author":"Freestone","year":"2000","journal-title":"J Bacteriol"},{"key":"10.1111\/2049-632X.12181-BIB0011|fim12181-cit-0011","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1574-6968.2006.00619.x","article-title":"Specificity of catecholamine-induced growth in Escherichia coli O157:H7, Salmonella enterica and Yersinia enterocolitica","volume":"269","author":"Freestone","year":"2007a","journal-title":"FEMS Microbiol Lett"},{"key":"10.1111\/2049-632X.12181-BIB0012|fim12181-cit-0012","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2180-7-8","article-title":"Blockade of catecholamine-induced growth by adrenergic and dopaminergic receptor antagonists in Escherichia coli O157:H7, Salmonella enterica and Yersinia enterocolitica","volume":"7","author":"Freestone","year":"2007b","journal-title":"BMC Microbiol"},{"key":"10.1111\/2049-632X.12181-BIB0013|fim12181-cit-0013","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/00000658-197307000-00020","article-title":"Plasma catecholamines in patients with serious postoperative infection","volume":"178","author":"Groves","year":"1973","journal-title":"Ann Surg"},{"key":"10.1111\/2049-632X.12181-BIB0014|fim12181-cit-0014","doi-asserted-by":"crossref","first-page":"6330","DOI":"10.1128\/jb.177.22.6330-6337.1995","article-title":"Pseudomonas aeruginosa sodA and sodB mutants defective in manganese- and iron-cofactored superoxide dismutase activity demonstrate the importance of the iron-cofactored form in aerobic metabolism","volume":"177","author":"Hassett","year":"1995","journal-title":"J Bacteriol"},{"key":"10.1111\/2049-632X.12181-BIB0015|fim12181-cit-0015","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00253-009-2045-1","article-title":"The neuroendocrine hormone norepinephrine increases Pseudomonas aeruginosa PA14 virulence through the las quorum-sensing pathway","volume":"84","author":"Hegde","year":"2009","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1111\/2049-632X.12181-BIB0016|fim12181-cit-0016","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrmicro1836","article-title":"Inter-kingdom signalling: communication between bacteria and their hosts","volume":"6","author":"Hughes","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"10.1111\/2049-632X.12181-BIB0017|fim12181-cit-0017","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1186\/1471-2164-9-458","article-title":"Adrenaline modulates the global transcriptional profile of Salmonella revealing a role in the antimicrobial peptide and oxidative stress resistance responses","volume":"9","author":"Karavolos","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1111\/2049-632X.12181-BIB0018|fim12181-cit-0018","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/embor.2011.4","article-title":"Salmonella Typhi sense host neuroendocrine stress hormones and release the toxin haemolysin E","volume":"12","author":"Karavolos","year":"2011","journal-title":"EMBO Rep"},{"key":"10.1111\/2049-632X.12181-BIB0019|fim12181-cit-0019","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/mmi.12110","article-title":"Pathogen espionage: multiple bacterial adrenergic sensors eavesdrop on host communication systems","volume":"87","author":"Karavolos","year":"2013","journal-title":"Mol Microbiol"},{"key":"10.1111\/2049-632X.12181-BIB0020|fim12181-cit-0020","first-page":"E284","article-title":"Plasma NE concentrations do not accurately reflect sympathetic nervous system activity in human sepsis","volume":"265","author":"Leinhardt","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1111\/2049-632X.12181-BIB0021|fim12181-cit-0021","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.4269\/ajtmh.2010.10-0038","article-title":"Increasing incidence of human melioidosis in Northeast Thailand","volume":"82","author":"Limmathurotsakul","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"10.1111\/2049-632X.12181-BIB0022|fim12181-cit-0022","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1073\/pnas.91.4.1328","article-title":"NADPH: ferredoxin oxidoreductase acts as a paraquat diaphorase and is a member of the soxRS regulon","volume":"91","author":"Liochev","year":"1994","journal-title":"P Natl Acad Sci USA"},{"key":"10.1111\/2049-632X.12181-BIB0023|fim12181-cit-0023","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1111\/2049-632X.12181-BIB0024|fim12181-cit-0024","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0378-1119(00)00279-1","article-title":"Characterization and mutagenesis of fur gene from Burkholderia pseudomallei","volume":"254","author":"Loprasert","year":"2000","journal-title":"Gene"},{"key":"10.1111\/2049-632X.12181-BIB0025|fim12181-cit-0025","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0022-2143(96)80011-4","article-title":"Production of Shiga-like toxins by Escherichia coli O157:H7 can be influenced by the neuroendocrine hormone norepinephrine","volume":"128","author":"Lyte","year":"1996","journal-title":"J Lab Clin Med"},{"key":"10.1111\/2049-632X.12181-BIB0026|fim12181-cit-0026","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ijmm.2007.07.013","article-title":"Effect of norepinephrine on colonisation and systemic spread of Salmonella enterica in infected animals: role of catecholate siderophore precursors and degradation products","volume":"298","author":"Methner","year":"2008","journal-title":"Int J Med Microbiol"},{"key":"10.1111\/2049-632X.12181-BIB0027|fim12181-cit-0027","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1128\/IAI.01038-09","article-title":"QseC mediates Salmonella enterica serovar Typhimurium virulence in vitro and in vivo","volume":"78","author":"Moreira","year":"2010","journal-title":"Infect Immun"},{"key":"10.1111\/2049-632X.12181-BIB0028|fim12181-cit-0028","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00203-008-0413-3","article-title":"Inactivation of Burkholderia pseudomallei bsaQ results in decreased invasion efficiency and delayed escape of bacteria from endocytic vesicles","volume":"190","author":"Muangsombut","year":"2008","journal-title":"Arch Microbiol"},{"key":"10.1111\/2049-632X.12181-BIB0029|fim12181-cit-0029","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1086\/513275","article-title":"Modulation of pathogenicity with norepinephrine related to the type III secretion system of Vibrio parahaemolyticus","volume":"195","author":"Nakano","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1111\/2049-632X.12181-BIB0030|fim12181-cit-0030","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1128\/IAI.01203-09","article-title":"Norepinephrine augments Salmonella enterica-induced enteritis in a manner associated with increased net replication but independent of the putative adrenergic sensor kinases QseC and QseE","volume":"78","author":"Pullinger","year":"2010","journal-title":"Infect Immun"},{"key":"10.1111\/2049-632X.12181-BIB0031|fim12181-cit-0031","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jemermed.2006.05.008","article-title":"Management of sepsis during the early \u201cgolden hours\u201d","volume":"31","author":"Raghavan","year":"2006","journal-title":"J Emerg Med"},{"key":"10.1111\/2049-632X.12181-BIB0032|fim12181-cit-0032","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1160354","article-title":"Targeting QseC signaling and virulence for antibiotic development","volume":"321","author":"Rasko","year":"2008","journal-title":"Science"},{"issue":"Pt 1","key":"10.1111\/2049-632X.12181-BIB0033|fim12181-cit-0033","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/000456329303000107","article-title":"Plasma and 24 h-urinary catecholamine concentrations in normal and patient populations","volume":"30","author":"Ross","year":"1993","journal-title":"Ann Clin Biochem"},{"key":"10.1111\/2049-632X.12181-BIB0034|fim12181-cit-0034","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1128\/JB.01028-09","article-title":"Elucidation of the mechanism by which catecholamine stress hormones liberate iron from the innate immune defense proteins transferrin and lactoferrin","volume":"192","author":"Sandrini","year":"2010","journal-title":"J Bacteriol"},{"key":"10.1111\/2049-632X.12181-BIB0035|fim12181-cit-0035","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1073\/pnas.1537100100","article-title":"Bacteria-host communication: the language of hormones","volume":"100","author":"Sperandio","year":"2003","journal-title":"P Natl Acad Sci USA"},{"key":"10.1111\/2049-632X.12181-BIB0036|fim12181-cit-0036","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1046\/j.1365-2958.2002.03190.x","article-title":"An Inv\/Mxi-Spa-like type III protein secretion system in Burkholderia pseudomallei modulates intracellular behaviour of the pathogen","volume":"46","author":"Stevens","year":"2002","journal-title":"Mol Microbiol"},{"key":"10.1111\/2049-632X.12181-BIB0037|fim12181-cit-0037","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1128\/JB.185.16.4992-4996.2003","article-title":"A Burkholderia pseudomallei type III secreted protein, BopE, facilitates bacterial invasion of epithelial cells and exhibits guanine nucleotide exchange factor activity","volume":"185","author":"Stevens","year":"2003","journal-title":"J Bacteriol"},{"key":"10.1111\/2049-632X.12181-BIB0038|fim12181-cit-0038","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1099\/mic.0.27146-0","article-title":"Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosis","volume":"150","author":"Stevens","year":"2004","journal-title":"Microbiology"},{"key":"10.1111\/2049-632X.12181-BIB0039|fim12181-cit-0039","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.femsle.2005.09.043","article-title":"Genome-wide expression analysis of iron regulation in Burkholderia pseudomallei and Burkholderia mallei using DNA microarrays","volume":"252","author":"Tuanyok","year":"2005","journal-title":"FEMS Microbiol Lett"},{"key":"10.1111\/2049-632X.12181-BIB0040|fim12181-cit-0040","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1099\/mic.0.050823-0","article-title":"Superoxide dismutase C is required for intracellular survival and virulence of Burkholderia pseudomallei","volume":"157","author":"Vanaporn","year":"2011","journal-title":"Microbiology"},{"key":"10.1111\/2049-632X.12181-BIB0041|fim12181-cit-0041","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.fsi.2011.01.019","article-title":"QseBC controls flagellar motility, fimbrial hemagglutination and intracellular virulence in fish pathogen Edwardsiella tarda","volume":"30","author":"Wang","year":"2011","journal-title":"Fish Shellfish Immun"},{"key":"10.1111\/2049-632X.12181-BIB0042|fim12181-cit-0042","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1056\/NEJMra1204699","article-title":"Melioidosis","volume":"367","author":"Wiersinga","year":"2012","journal-title":"N Engl J Med"}],"container-title":["Pathogens and Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femspd\/article-pdf\/72\/1\/24\/19131793\/72-1-24.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T03:54:18Z","timestamp":1503460458000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femspd\/article-lookup\/doi\/10.1111\/2049-632X.12181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,12]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,10]]}},"URL":"https:\/\/doi.org\/10.1111\/2049-632x.12181","relation":{},"ISSN":["2049-632X"],"issn-type":[{"value":"2049-632X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5,12]]}}}