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One week after withdrawal of maintenance, which had been given for 14 days, the challenge dose of fluvoxamine was still unable to raise plasma PRL levels. 5 The endocrine effects of acute fluvoxamine administration are compatible with activation of 5\u2010HT neurotransmission in the central nervous system. The mechanism(s) underlying tolerance to the PRL\u2010releasing action of the drug is presently obscure. 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