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Pain thresholds and plasma concentrations of the S\u2010 and R\u2010enantiomers of ibuprofen were measured every hour up to 8 h after medication. 3. Ibuprofen (400 mg) produced an analgesic effect significantly superior (P less than 0.05) to placebo 1\u20104 h after medication. Ibuprofen (800 mg) was significantly superior to placebo 2\u2010 4 h after administration. No differences were found between 400 mg and 800 mg, when hourly threshold differences were compared. 4. Comparing total analgesic effect (area under effect curve), both active medications were superior to placebo (P less than 0.01\u20100.05), and 400 mg was superior to 800 mg (P less than 0.05). 5. Peak plasma concentrations of S\u2010 and R\u2010ibuprofen occurred between 1.2 and 1.5 h. 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