{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:47:56Z","timestamp":1761518876784},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":6633,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>A selective inhibitor of aromatase is widely sought for the treatment of postmenopausal women with breast cancer. CGS 16949A has been shown to be a highly selective, potent inhibitor of aromatase <jats:italic>in vitro<\/jats:italic>. Its potency as an oestrogen suppressant and its selectivity were examined by treating 24 postmenopausal patients with advanced breast cancer for 4 weeks with doses of 0.3, 1\u20100 and 2\u20100 mg twice daily. The study was conducted in two parts which compared the two lower doses and the two higher doses separately in a cross\u2010over design protocol. All doses significantly suppressed serum oestradiol and oestrone levels below pretreatment levels. Cross\u2010over analysis indicated that the 2.0 mg twice daily dose achieved significantly greater suppression of oestradiol levels than 1\u20100 mg twice daily but there was no significant difference between any of the doses in the suppression of oestrone. No significant effects were noted on serum levels of LH, FSH, SHBG, prolactin, testosterone, androstenedione, 17\u2010 hydroxyprogesterone or cortisol. For the four steroids this was true both for basal samples and those collected after Synacthen stimulation. However, serum aldosterone levels were significantly suppressed by 1\u20100 mg twice daily CGS 16949A and further suppressed by 2\u20100 mg twice daily. It is concluded that CGS 16949A is a potent oestrogen suppressant in postmenopausal patients but that its effect is not totally selective.<\/jats:p>","DOI":"10.1111\/j.1365-2265.1990.tb00906.x","type":"journal-article","created":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T12:06:14Z","timestamp":1205755574000},"page":"623-634","source":"Crossref","is-referenced-by-count":57,"title":["POTENCY AND SELECTIVITY OF THE NON\u2010STEROIDAL AROMATASE INHIBITOR CGS 16949A IN POSTMENOPAUSAL BREAST CANCER PATIENTS"],"prefix":"10.1111","volume":"32","author":[{"given":"M.","family":"DOWSETT","sequence":"first","affiliation":[]},{"given":"R. C.","family":"STEIN","sequence":"additional","affiliation":[]},{"given":"A.","family":"MEHTA","sequence":"additional","affiliation":[]},{"given":"R. C.","family":"COOMBES","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(81)90087-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92795-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00570496"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-58-1-99"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1985.tb00228.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1985.223"},{"key":"e_1_2_1_8_1","first-page":"1957","article-title":"Use of the aromatase inhibitor 4\u2010hydroxyandrostenedione in postmenopausal breast cancer: optimization of therapeutic dose and route","volume":"47","author":"Dowsett M.","year":"1987","journal-title":"Cancer Research"},{"key":"e_1_2_1_9_1","first-page":"1306","article-title":"Dose\u2010related endocrine effects and pharmacokinetics of oral and intramuscular 4\u2010hydroxyandrostenedione in postmenopausal breast cancer patients","volume":"49","author":"Dowsett M.","year":"1989","journal-title":"Cancer Research"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(71)90109-0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456328201900507"},{"key":"e_1_2_1_12_1","first-page":"4823","article-title":"Treatment of advanced postmenopausal breast cancer with an aromatase inhibitor, 4\u2010hydroxyandrostenedione: phase II report","volume":"46","author":"Goss P. E.","year":"1986","journal-title":"Cancer Research"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-55-4-718"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(83)90112-8"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1983.100"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1983.232"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1979.tb05903.x"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.46.537.409"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19660490113"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-85-2-270"},{"key":"e_1_2_1_21_1","first-page":"109","volume-title":"Treatment of Advanced Metastatic Breast Cancer, Carcinoma of the Prostate, and Endometrial Cancer with Aminoglutethimide","author":"Murray R. M. L.","year":"1984"},{"key":"e_1_2_1_22_1","first-page":"331","volume-title":"Hormonal Manipulation of Cancer: Peptides, Growth Factors, and New (Anti) Steroidal Agents","author":"Nicholson R. I.","year":"1987"},{"key":"e_1_2_1_23_1","first-page":"661","article-title":"Successful medical adrenalectomy with aminoglutethimide. Role of altered drug metabolism","volume":"230","author":"Santen R. J.","year":"1974","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-47-6-1257"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-68-1-99"},{"key":"e_1_2_1_26_1","first-page":"834","article-title":"CGS 16949A, a new nonsteroidal aromatase inhibitor: effects on hormone\u2010dependent and \u2010independent tumours in vivo","volume":"48","author":"Schieweck K.","year":"1988","journal-title":"Cancer Research"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(83)90068-5"},{"key":"e_1_2_1_28_1","unstructured":"Stein R. C. Dowsett M. Davenport J. Hedley A.andCoombes R. C.Preliminary study of the treatment of advanced breast cancer in postmenopausal women with the aromatase inhibitor CGS 16949A Cancer Research (in press)."},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90596-8"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1985.tb01083.x"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-7372(84)90008-2"},{"key":"e_1_2_1_32_1","first-page":"517","article-title":"Aminoglutethimide and glutethimide: effects on 18\u2010hydroxycorticosterone biosynthesis by human and sheep adrenals in vitro","volume":"80","author":"Touitou Y.","year":"1975","journal-title":"Acta Endocrinologica"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1983.tb00044.x"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.1990.tb00906.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.1990.tb00906.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T20:30:26Z","timestamp":1698006626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.1990.tb00906.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1990,5]]}},"alternative-id":["10.1111\/j.1365-2265.1990.tb00906.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.1990.tb00906.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,5]]}}}