{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:09:21Z","timestamp":1773274161861,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,7,5]],"date-time":"2005-07-05T00:00:00Z","timestamp":1120521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Familial nonmedullary thyroid cancer (FNMTC) is relatively common but its predisposing genetic alteration is unclear. As the somatic T1799A <jats:italic>BRAF<\/jats:italic> mutation is highly prevalent in papillary thyroid cancer, the aim was to test whether this mutation was a susceptibility mutation for FNMTC.<\/jats:p><jats:p><jats:bold>Subjects and methods\u2002<\/jats:bold> The T1799A <jats:italic>BRAF<\/jats:italic> mutation as a possible germline mutation was examined in 40 subjects from 23 families with a history of FNMTC. Direct DNA sequencing was performed on white blood cell DNA samples to analyse the mutation status.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> No T1799A <jats:italic>BRAF<\/jats:italic> mutation was found in this group of subjects as germline mutation.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The T1799A <jats:italic>BRAF<\/jats:italic> mutation is not a germline mutation or susceptibility genetic event for FNMTC.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2005.02332.x","type":"journal-article","created":{"date-parts":[[2005,8,16]],"date-time":"2005-08-16T14:56:48Z","timestamp":1124204208000},"page":"263-266","source":"Crossref","is-referenced-by-count":30,"title":["The T1799A <i>BRAF<\/i> mutation is not a germline mutation in familial nonmedullary thyroid cancer"],"prefix":"10.1111","volume":"63","author":[{"given":"Mingzhao","family":"Xing","sequence":"first","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,7,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981215)83:12<2638::AID-CNCR31>3.0.CO;2-1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-000-0050-9"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1210\/jcem.87.6.8670","article-title":"The genetics of hereditary nonmedullary thyroid carcinoma","volume":"87","author":"Malchoff C.D.","year":"2002","journal-title":"Journal of Clinical Endocrinology and 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man","volume":"7","author":"Sithanandam G.","year":"1992","journal-title":"Oncogene"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1086\/302164"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.5.1758"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10188"},{"key":"e_1_2_5_24_2","first-page":"3061","article-title":"BRAF as a melanoma susceptibility candidate gene?","volume":"63","author":"Laud K.","year":"2003","journal-title":"Cancer Research"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.07.112"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1955.01270120131015"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/321979"}],"container-title":["Clinical 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