{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:17:36Z","timestamp":1769725056362,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,4,3]],"date-time":"2007-04-03T00:00:00Z","timestamp":1175558400000},"content-version":"vor","delay-in-days":4567,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:p>Thirty\u2010nine resection specimens of gastric carcinomas have been investigated for the presence of EBV RNA sequences using a highly sensitive non\u2010radioactive <jats:italic>in situ<\/jats:italic> hybridization technique. Transcribed EBER sequences were found in seven (18%), including four cases of undifferentiated carcinoma with prominent lymphoid infiltration and three gastric adenocarcinomas. In the positive tumours all, or nearly all, tumour nuclei were distinctly labelled. No positive signals could be detected in the non\u2010dysplastic epithelial cells or the reactive inflammatory infiltrate. Clonality analysis using specific probes to the variable tandem repeat region of the EBV yielded single episomal bands in all four cases tested, two of which were undifferentiated carcinomas and two adenocarcinomas. By means of immunohistology, no expression of the EBV\u2010related proteins LMP or EBNA\u20102 was present in tumour cells of positive cases in <jats:italic>in situ<\/jats:italic> or blotting attempts. Our results suggest that infection of gastric carcinomas by the EB virus occurs early in tumourigenesis but, in contrast to nasopharyngeal carcinomas, does not result in the expression of EBV\u2010specific proteins.<\/jats:p>","DOI":"10.1111\/j.1365-2559.1994.tb01350.x","type":"journal-article","created":{"date-parts":[[2007,4,3]],"date-time":"2007-04-03T14:34:14Z","timestamp":1175610854000},"page":"323-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Monoclonal Epstein\u2010Barr virus genomes but lack of EBV\u2010related protein expression in different types of gastric carcinoma"],"prefix":"10.1111","volume":"25","author":[{"given":"G.","family":"OTT","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TH.","family":"KIRCHNER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.K.","family":"M\u00dcLLER\u2010HERMELINK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198309000-00012"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-4-538"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90093-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/91.1.1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90002-M"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1182\/blood.V77.4.799.799","article-title":"Aggressive peripheral T\u2010cell lymphomas containing Epstein\u2010Barr viral DNA. A clinicopathological and molecular analysis","volume":"77","author":"Su IJ","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910510410"},{"key":"e_1_2_1_9_2","first-page":"86","article-title":"Epstein\u2010Barr viral DNA in tissues of Hodgkin's disease","volume":"129","author":"Weiss LM","year":"1987","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_10_2","first-page":"13","article-title":"High incidence of Epstein\u2010Barr virus genomes in Hodgkin's disease","volume":"137","author":"Herbst H","year":"1990","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/2281056a0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910160103"},{"key":"e_1_2_1_13_2","first-page":"1461","article-title":"Abundant expression of EBER1 small nuclear RNA in nasopharyngeal carcinoma\u2014A morphologically distinctive target for detection of Epstein\u2010Barr virus in formalin\u2010fixed, paraffin\u2010embedded carcinoma specimens","volume":"138","author":"Wu TC","year":"1991","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_14_2","first-page":"879","article-title":"Expression of Epstein\u2010Barr virus genes and of lymphocyte activation molecules in undifferentiated nasopharyngeal carcinomas","volume":"140","author":"Niedobitek G","year":"1992","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90803-2"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80641-4"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80214-9"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198512000-00004"},{"key":"e_1_2_1_19_2","first-page":"359","article-title":"Lymphoepithelioma\u2010like carcinoma of the skin","volume":"1","author":"Swanson SA","year":"1988","journal-title":"Mod. Pathol."},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198908000-00002"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198505163122006"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198908000-00001"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1965.64.1.31"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1982.264"},{"key":"e_1_2_1_25_2","first-page":"363","article-title":"In situ localization of Epstein\u2010Barr virus in thymic carcinoma","volume":"5","author":"Mann RB","year":"1992","journal-title":"Mod. Pathol."},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1992.tb00075.x"},{"key":"e_1_2_1_27_2","first-page":"377","article-title":"Lymphoepithelial carcinoma of the stomach with Epstein\u2010Barr virus demonstrated by polymerase chain reaction","volume":"3","author":"Burke AP","year":"1990","journal-title":"Mod. Pathol."},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/96.2.219"},{"key":"e_1_2_1_29_2","first-page":"469","article-title":"Association of Epstein\u2010Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. Lymphoepithelioma\u2010like carcinoma","volume":"139","author":"Shibata D","year":"1991","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_30_2","first-page":"769","article-title":"Epstein\u2010Barr virus associated gastric adenocarcinoma","volume":"140","author":"Shibata D","year":"1992","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910530605"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1128\/jvi.66.5.2689-2697.1992","article-title":"Epstein\u2010Barr virus latent gene transcription in nasopharyngeal carcinoma cells: coexpression of EBNA1, LMP1 and LMP2 transcripts","volume":"66","author":"Brooks L","year":"1992","journal-title":"J. Virol."},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.66.5.3257-3262.1992"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/344777a0"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/345447a0"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02899665"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-69-5-1051"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.11.4766"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.1.217.bloodjournal821217"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2559.1994.tb01350.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2559.1994.tb01350.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T23:32:27Z","timestamp":1698103947000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2559.1994.tb01350.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["10.1111\/j.1365-2559.1994.tb01350.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2559.1994.tb01350.x","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10]]},"assertion":[{"value":"2007-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}