{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T09:15:22Z","timestamp":1768727722577,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T00:00:00Z","timestamp":1164585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> To determine the platelet\u2010derived growth factor (PDGF) \u03b1 and \u03b2 status of desmoid tumours. Desmoid tumours are rare monoclonal neoplasms that appear to have no metastatic potential. Surgical resection and radiotherapy in the event of a positive surgical margin is the first\u2010line treatment. Recurrences are frequent. Treatment results using non\u2010steroidal anti\u2010inflammatory agents, anti\u2010oestrogen compounds and other agents such as Imatinib mesylate have been published. Therapy with Imatinib has been proposed as a therapeutic option, although in most reports desmoid tumours are reported to be c\u2010kit\u2013.<\/jats:p><jats:p><jats:bold>Methods and results:\u2002<\/jats:bold> We performed immunohistochemical analysis on 124 archived samples (85 patients) of desmoid tumours using antibodies to PDGF\u03b1, PDGF\u03b2, PDGFR\u03b1 and PDGFR\u03b2. All desmoid tumours showed immunoreactivity with antibodies to PDGF\u03b1 and PDGFR\u03b1, whereas with antibodies to PDGF\u03b2 and PDGFR\u03b2 no specific reaction could be detected. Mutational analysis of <jats:italic>PDGFR\u03b1<\/jats:italic> (exons 11, 12, 17 and 18) and <jats:italic>PDGFR\u03b2<\/jats:italic> (exon 12) on frozen material from 14 patients was performed, but no mutations leading to amino acid changes in the mature protein were identified.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The absence of an activating mutation in a protooncogene does not exclude the efficacy of tyrosine kinase inhibitors through other possible mechanisms, and these might be a therapeutic option for patients with desmoid tumours in whom established local and systemic approaches fail to control the disease.<\/jats:p>","DOI":"10.1111\/j.1365-2559.2006.02562.x","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T20:12:07Z","timestamp":1164658327000},"page":"576-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Immunohistochemical and mutational analysis of PDGF and PDGFR in desmoid tumours: is there a role for tyrosine kinase inhibitors in c\u2010kit\u2010negative desmoid tumours?"],"prefix":"10.1111","volume":"49","author":[{"given":"B","family":"Liegl","sequence":"first","affiliation":[]},{"given":"A","family":"Leithner","sequence":"additional","affiliation":[]},{"given":"T","family":"Bauernhofer","sequence":"additional","affiliation":[]},{"given":"R","family":"Windhager","sequence":"additional","affiliation":[]},{"given":"C","family":"Guelly","sequence":"additional","affiliation":[]},{"given":"S","family":"Regauer","sequence":"additional","affiliation":[]},{"given":"A","family":"Beham","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,11,27]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"309","volume-title":"Soft tissue tumors","author":"Weiss SW","year":"2001"},{"key":"e_1_2_7_3_2","first-page":"376","article-title":"Follow\u2010up study of a family group exhibiting dominant inheritance for a syndrome including intestinal polyps, osteomas, fibromas and epidermal cysts","volume":"14","author":"Gardner EJ","year":"1962","journal-title":"Am. 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