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Here we report for the first time that CD45<jats:sup>\u2013\/\u2013<\/jats:sup> bone marrow dendritic cells (BMDC) are more activated than CD45<jats:sup>+\/+<\/jats:sup> cells and that tumour necrosis factor (TNF) and interleukin\u20106 (IL\u20106) production by BMDC and splenic dendritic cells (sDC), is increased following stimulation via Toll\u2010like receptor (TLR)3 and TLR9. Nuclear factor\u2010\u03baB activation, an important downstream consequence of TLR3 and TLR9 signalling, is also increased in CD45<jats:sup>\u2013\/\u2013<\/jats:sup> BMDC. BMDC of CD45<jats:sup>\u2013\/\u2013<\/jats:sup> mice also produce more TNF and IL\u20106 following stimulation with the cytokines TNF and interferon\u2010\u03b1. These results show that TLR signalling is increased in CD45<jats:sup>\u2013\/\u2013<\/jats:sup> dendritic cells and imply that CD45 is a negative regulator of TLR and cytokine receptor signalling in dendritic cells.<\/jats:p>","DOI":"10.1111\/j.1365-2567.2006.02363.x","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T15:19:04Z","timestamp":1147447144000},"page":"250-256","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["CD45 negatively regulates tumour necrosis factor and interleukin\u20106 production in dendritic cells"],"prefix":"10.1111","volume":"118","author":[{"given":"Jenny","family":"Piercy","sequence":"first","affiliation":[]},{"given":"Svetla","family":"Petrova","sequence":"additional","affiliation":[]},{"given":"Elma Z.","family":"Tchilian","sequence":"additional","affiliation":[]},{"given":"Peter C. 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