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Expression of <jats:italic>katG<\/jats:italic> restored full drug susceptibility in isolates initially resistant to concentrations ranging from 3.2 to &gt;50\u03bcgml<jats:sup>\u22121<\/jats:sup>. Transformation with the corresponding <jats:italic>katG<\/jats:italic> gene from <jats:italic>Escherichia coli<\/jats:italic> resulted in low\u2010level expression of catalase and peroxidase activities and conferred partial isoniazid sensitivity.<\/jats:p>","DOI":"10.1111\/j.1365-2958.1993.tb01596.x","type":"journal-article","created":{"date-parts":[[2006,10,28]],"date-time":"2006-10-28T01:25:32Z","timestamp":1161998732000},"page":"521-524","source":"Crossref","is-referenced-by-count":133,"title":["Transformation with <i>katG<\/i> restores isoniazid\u2010sensitivity in <i>Mycobacterium tuberculosis<\/i> isolates resistant to a range of drug concentrations"],"prefix":"10.1111","volume":"8","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Garbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.257.5073.1055"},{"key":"e_1_2_1_3_1","first-page":"585","article-title":"Nosocomial transmission of multidrug\u2010resistant tuberculosis among HIV\u2010infected persons \u2014 Florida and New York 1988\u20131991","volume":"40","author":"Centers for Disease Control","year":"1991","journal-title":"MMWR"},{"key":"e_1_2_1_4_1","first-page":"641","article-title":"Studies on isoniazid and tubercle bacilli: II. 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