{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T08:41:07Z","timestamp":1698223267361},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,10,9]],"date-time":"2007-10-09T00:00:00Z","timestamp":1191888000000},"content-version":"vor","delay-in-days":8682,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:p><jats:bold>Summary<\/jats:bold> The surface composition of three stages in the life cycle of <jats:italic>Litomosoides carinii<\/jats:italic>, a filarial parasite of rodents, has been studied using radio\u2010iodination techniques. Confirmation that radiolabeled components were confined to the parasite surface was achieved using light and electron microscope autoradiography. Biochemical analysis of extracts of radiolabeled parasites by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS\u2010PAGE) revealed that one major component (mol. wt. 55000) could be solubilized with the aid of detergents. This component, which was present on male and female adult worms and on post\u2010parasitic third stage larvae, accounted for about one\u2010third of the total proteins available for surface iodination, and was antigenic in infected hosts. The remaining surface components could be solubilized only with urea and SDS under reducing conditions. The 55 000 mol. wt. surface antigens of male and female adult worms exhibited identical two\u2010dimensional tryptic maps, but the similar 55 000 mol.wt. antigen of post\u2010parasitic third stage larvae was different. There was, however, some sharing of antigenic determinants between adult and larval surface components. The principal protein present in detergent extracts of surface\u2010radio\u2010labelled blood microfilariae was host serum albumin.<\/jats:p>","DOI":"10.1111\/j.1365-3024.1984.tb00782.x","type":"journal-article","created":{"date-parts":[[2007,10,9]],"date-time":"2007-10-09T14:05:20Z","timestamp":1191938720000},"page":"63-82","source":"Crossref","is-referenced-by-count":38,"title":["Surface proteins of a filarial nematode: a major soluble antigen and a host component on the cuticle of <i>Litomosoides carinii<\/i>"],"prefix":"10.1111","volume":"6","author":[{"given":"M.","family":"PHILIPP","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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OGILVIE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.M.","family":"PARKHOUSE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PATRICIA M.","family":"TAYLOR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,9]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.2307\/3277514"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/3277515"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/228682a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(82)90068-6"},{"key":"e_1_2_1_5_1","first-page":"213","volume-title":"Nematodes as Biological Models","author":"Bird A.F.","year":"1980"},{"key":"e_1_2_1_6_1","first-page":"161","article-title":"Shared antigens between Litomosoides carinii and its hosts Sigmodon hispidus and Mostomys natalensis","volume":"32","author":"Court J.P.","year":"1981","journal-title":"Tropenmedizin und Parasitologic"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.99.2569.245"},{"key":"e_1_2_1_8_1","first-page":"271","article-title":"Experimental transmission of Onchocerca volvulus from man to a chimpanzee","volume":"56","author":"Duke B.O.L.","year":"1962","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"6510","DOI":"10.1016\/S0021-9258(17)39987-8","article-title":"Tryptic peptide analysis of all the major members of complex multicomponent systems using microgram quantities of total protein","volume":"252","author":"Elder J.H.","year":"1977","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00652a013"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0006-3002(53)90233-9","article-title":"Methode permettant l'etude conjugee des proprietes electrophorettiques et immunochimiques d'un melange de proteines. 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