{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:16:07Z","timestamp":1762928167405},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,3,2]],"date-time":"2012-03-02T00:00:00Z","timestamp":1330646400000},"content-version":"vor","delay-in-days":9437,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:p><jats:bold>Summary<\/jats:bold> Serum was obtained from CBA\/Ca mice infected, reinfected or superinfected with parasites taken one or two syringe passages from cryopreserved reference stabilates derived from cloned lines of the AS or CB isolates of <jats:italic>P.c. chabaudi.<\/jats:italic> Serum was also collected from mice superinfected with parasites derived from a cloned line of <jats:italic>P. berghei<\/jats:italic> KSP\u201011. When injected into normal syngeneic recipients subsequently challenged with homologous or heterologous parasites, these sera mediated some or all of the following modifications to the breakthrough parasitaemias which invariably occurred (i) an extension of the pre\u2010patent period (ii) an extension of the time taken for the parasitaemia to reach 2% (iii) a reduction of peak parasitaemia (iv) protraction of the initial peak of parasitaemia. These modifications were particularly evident with serum from superinfected mice and to a lesser extent with serum from animals reinfected once after recovery from a primary infection. Serum taken during the course of such a primary infection produced extended pre\u20102% periods, other effects being only marginal. Serum mediated modifications produced by reinfection and superinfection serum appeared largely species\u2010specific with a limited degree of cross\u2010reactivity. Intraspecific specificity was also apparent with serum from <jats:italic>P.c. chabaudi<\/jats:italic> AS or CB reinfected or superinfected mice, although marginal cross\u2010immunity was again observed. When analysed by the fluorescent antibody technique on smears of methanol fixed parasitized erythrocytes, reinfection and superinfection sera were almost totally cross\u2010reactive both within and across species. Preliminary evidence that parasites breaking through the effects of these sera may constitute a phenotypic antigenic variant is presented and possible mechanisms for the parasitaemia modifying effects of the various sera discussed.<\/jats:p>","DOI":"10.1111\/j.1365-3024.1986.tb01036.x","type":"journal-article","created":{"date-parts":[[2012,3,4]],"date-time":"2012-03-04T03:59:10Z","timestamp":1330833550000},"page":"239-254","source":"Crossref","is-referenced-by-count":42,"title":["Protective immunity to malaria. Studies with cloned lines of <i>Plasmodium chabaudi chabaudi<\/i> and <i>P. berghei<\/i> in CBA\/Ca mice. II. The effectiveness and inter\u2010 or intra\u2010species specificity of the passive transfer of immunity with serum"],"prefix":"10.1111","volume":"8","author":[{"given":"W.","family":"JARRA","sequence":"first","affiliation":[]},{"given":"L.A.","family":"HILLS","sequence":"additional","affiliation":[]},{"given":"J.C.","family":"MARCH","sequence":"additional","affiliation":[]},{"given":"K.N.","family":"BROWN","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2012,3,2]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"732","article-title":"Immunity to rodent malaria: Isolation and characterization of protective antibody","volume":"69","author":"Ananthanarayanan M.","year":"1979","journal-title":"Indian Journal of Medical Research"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1128\/iai.38.1.94-102.1982","article-title":"Monoclonal antibodies protecting in vivo against the rodent malaria Plasmodium chabaudi recognise a 250 000 Dalton parasite polypeptide","volume":"38","author":"Boyle D.B.","year":"1982","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1093\/milmed\/131.suppl_9.1243","article-title":"Effects of rat antiserum on the course of Plasmodium berghei infection in mice","volume":"131","author":"Briggs N.T.","year":"1966","journal-title":"Military Medicine (Supplement\u2014Research in Malaria)"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1128\/iai.39.3.1228-1235.1983","article-title":"Differential effect of immunoglobulin on the in vitro growth of several isolates of Plasmodium falciparum","volume":"39","author":"Brown G.V.","year":"1983","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470720073.ch4"},{"key":"e_1_2_1_7_1","first-page":"268","volume-title":"Immunology of Parasitic Infections","author":"Brown K.N.","year":"1976"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-3424-8_6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0769-2625(85)80036-2"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90114-7"},{"key":"e_1_2_1_11_1","first-page":"339","article-title":"Biochemical markers for strain differentiation in malarial parasites","volume":"55","author":"Carter R.","year":"1977","journal-title":"Bulletin of the World Health Organisation"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1979.0001"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/223368a0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1980.29.1143"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.4049\/jimmunol.102.2.298","article-title":"Humoral immunity in rodent malaria II. 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