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To identify such genes, data from published <jats:italic>Arabidopsis thaliana<\/jats:italic> abiotic stress microarray analyses were combined with our presented global analysis of early heat stress\u2010responsive gene expression, in a relational database. A set of <jats:italic>Multiple Stress<\/jats:italic> (<jats:italic>MST<\/jats:italic>) genes was identified by scoring each gene for the number of abiotic stresses affecting expression of that gene. ErmineJ over\u2010representation analysis of the <jats:italic>MST<\/jats:italic> gene set identified significantly enriched gene ontology biological processes for multiple abiotic stresses and regulatory genes, particularly transcription factors. A subset of <jats:italic>MST<\/jats:italic> genes including only regulatory genes that were designated \u2018<jats:italic>Multiple Stress Regulatory<\/jats:italic>\u2019 (<jats:italic>MSTR<\/jats:italic>) genes, was identified. To validate this strategy for identifying <jats:italic>MSTR<\/jats:italic> genes, mutants of the highest\u2010scoring <jats:italic>MSTR<\/jats:italic> gene encoding the circadian clock protein CCA1, were tested for altered sensitivity to stress. A double mutant of CCA1 and its structural and functional homolog, LATE ELONGLATED HYPOCOTYL, exhibited greater sensitivity to salt, osmotic and heat stress than wild\u2010type plants. This work provides a reference data set for further study of <jats:italic>MSTR<\/jats:italic> genes.<\/jats:p>","DOI":"10.1111\/j.1365-3040.2008.01779.x","type":"journal-article","created":{"date-parts":[[2008,3,5]],"date-time":"2008-03-05T12:43:31Z","timestamp":1204721011000},"page":"697-714","source":"Crossref","is-referenced-by-count":100,"title":["Functional\u2010genomics\u2010based identification of genes that regulate <i>Arabidopsis<\/i> responses to multiple abiotic stresses"],"prefix":"10.1111","volume":"31","author":[{"given":"PRAGYA","family":"KANT","sequence":"first","affiliation":[]},{"given":"MICHAL","family":"GORDON","sequence":"additional","affiliation":[]},{"given":"SURYA","family":"KANT","sequence":"additional","affiliation":[]},{"given":"GASTON","family":"ZOLLA","sequence":"additional","affiliation":[]},{"given":"OLGA","family":"DAVYDOV","sequence":"additional","affiliation":[]},{"given":"YAIR 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