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Spleen cells from dextran\u2010primed and\u2010suppressed mice responded well to dextran after transfer to lethally irradiated previously untreated mice, indicating that tolerance or exhaustive proliferation of dextran reactive B cells is not responsible. Thymus\u2010dependent dextran\u2013protein conjugates also induced specific suppression. Suppression to both dextran and horse erythrocyte could be passively transferred into untreated recipients with immune serum. However, after absorption with horse erythrocytes and dextran, passive serum transfer only suppressed the response to dextran. It is suggested that the specific immunosuppression was caused by the appearance of autoanti\u2010idtotypic antibodies directed against the immunoglobulin receptors of dextran\u2010reactive B cells.<\/jats:p>","DOI":"10.1111\/j.1365-3083.1980.tb00208.x","type":"journal-article","created":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T13:46:44Z","timestamp":1151675204000},"page":"53-62","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A Primary Immune Response to Dextran B512 is Followed by a Period of Antigen\u2010specific Immunosuppression Caused by Autoanti\u2010idiotypic Antibodies"],"prefix":"10.1111","volume":"11","author":[{"given":"C.","family":"FERNANDEZ","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"M\u00d6LLER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.4049\/jimmunol.100.6.1326","article-title":"Regulation of antibody synthesis against E. coli endotoxin. 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