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The adjuvants inliueneed the isolype of antibodies produced to the same antigenic determinant. The PFC of different IgG subclasses were favoured by different adjuvants. The IgG3 isotype was produecd mainly alter immunization with either anligen and lipopolysaccharide(LPS)or Li sail asadjusani; IgGI was produced with incomplete Feund's adjuvant (IFA), complete Freund's adjuvani (CFA), alum, poly I:C. Quil A, Be salt, and poly A:U. Some of the above adjuvanis (Be salt and poly A:U) favoured the production of lgG2b, and others (CFA, alum. Quil A, and poly I:C) favoured ihe IgG2a isotype besides the main isotype. Attempts were made to correlate the activation by the various adjuvants of certain T<jats:sub>H<\/jats:sub> subtypes with the isotypes produced.<\/jats:p>","DOI":"10.1111\/j.1365-3083.1990.tb02826.x","type":"journal-article","created":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T22:01:14Z","timestamp":1151704874000},"page":"745-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Regulation of Isotype Immunoglobulin Production by Adjuvants in Vivo"],"prefix":"10.1111","volume":"31","author":[{"given":"E. 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