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This class of proteins is involved in the transport of intermediates of the tetrapyrrole biosynthesis pathway. Like the mammalian homologue, the PpTSPO1 protein is localized to mitochondria. The generation of <jats:italic>PpTSPO1<\/jats:italic>\u2010targeted moss knock\u2010out lines revealed an essential function of the gene in abiotic stress adaptation. Under stress conditions, the <jats:italic>PpTSPO1<\/jats:italic> null mutants show elevated H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> levels, enhanced lipid peroxidation and cell death, indicating an important role of PpTSPO1 in redox homeostasis. 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