{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:48:51Z","timestamp":1772898531044,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,28]],"date-time":"2007-04-28T00:00:00Z","timestamp":1177718400000},"content-version":"vor","delay-in-days":6479,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[1989,8]]},"abstract":"<jats:p>Sixty\u2010seven patients with a history of severe systemic reactions following honey bee stings were treated by immunotherapy (IT) with honey bee venom. During maintenance therapy all were submitted to a sting challenge under clinical conditions. 15 developed mostly minor symptoms of a systemic reaction while 52 showed only a local swelling at the sting site. Phospholipase A<jats:sub>2<\/jats:sub>\u2010specific IgE, IgG and IgG subclass serum antibodies were estimated in samples obtained before IT and immediately before the challenge. Specific IgE decreased in reactors and in non\u2010reactors. There was no difference between the two groups at any time. Specific total IgG, IgG<jats:sub>1<\/jats:sub> and IgG<jats:sub>4<\/jats:sub> increased in both reactors and non\u2010reactors during IT. An early increase of specific IgG<jats:sub>1<\/jats:sub>, was observed while specific IgG<jats:sub>4<\/jats:sub> remained elevated throughout the treatment. Specific total IgG was higher in reactors than non\u2010reactors before the challenge, specific IgG<jats:sub>1<\/jats:sub> higher in reactors before treatment and specific IgG<jats:sub>4<\/jats:sub> higher in reactors than non\u2010reactors both before treatment and before challenge. In the individual patient, no single antibody estimation or combination of various antibodies was predictive of the outcome of a sting challenge.<\/jats:p>","DOI":"10.1111\/j.1398-9995.1989.tb04172.x","type":"journal-article","created":{"date-parts":[[2007,5,13]],"date-time":"2007-05-13T23:49:20Z","timestamp":1179100160000},"page":"412-418","source":"Crossref","is-referenced-by-count":138,"title":["Predictive value of venom\u2010specific IgE, IgG and IgG subclass antibodies in patients on immunotherapy with honey bee venom"],"prefix":"10.1111","volume":"44","author":[{"given":"U.","family":"M\u00dcLLER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"HELBLING","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"BISCHOF","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.4049\/jimmunol.130.2.722","article-title":"Serologic aspects of IgG antibodies.I. Prolonged immunization results in an IgG4\u2010restricted response","volume":"130","author":"Aalberse R. C.","year":"1983","journal-title":"J. Immunol."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(85)90029-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(87)90245-4"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80470-7"},{"key":"e_1_2_1_6_2","first-page":"142","article-title":"A comparison of venom concentrations of 0.1 mcg\/ml and 1.0 mcg\/ml as indicator of sensitivity to honey bee stings.","volume":"77","author":"Day J. H.","year":"1986","journal-title":"J. Allergy Clin. Imunol."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1984.tb01965.x"},{"key":"e_1_2_1_8_2","first-page":"267","article-title":"Long\u2010term IgG4 determinations in Hymenoptera\u2010sensitive treated patients.","volume":"59","author":"Gentlesk M. 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