{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:44:30Z","timestamp":1774665870051,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,28]],"date-time":"2007-04-28T00:00:00Z","timestamp":1177718400000},"content-version":"vor","delay-in-days":4684,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:p>Brambilla C, Chastang C, Georges D, Bertin L. Salmeterol compared with slow\u2010release terbutaline in nocturnal asthma. A multicenter, randomized, double\u2010blind, double\u2010dummy, sequential clinical trial.<\/jats:p><jats:p>The aim of the multicenter, randomized, double\u2010blind, double\u2010dummy, parallel\u2010group clinical trial with a 2\u2010week treatment period was to compare the efficacy and safety of salmeterol (50 ug twice daily) with slow\u2010release (SR) terbutaline (5 \u03bcg orally, twice daily) in nocturnal asthma. A total of 159 asthmatic adults (FEV, 50\u201090% of predicted value; sex ratio: 0.87) with at least two nocturnal awakenings during a 7\u2010d run\u2010in period was included in the study. Patients were centrally randomized with a national computer network (Minitel\u00ae). The main variable (number of awakening\u2010free nights during the last week of treatment) was analyzed according to a sequential method with the one\u2010sided triangular test. The number of awakening\u2010free nights (\u00b1 SD) was significantly higher in the salmeterol group: 5.3 \u00b1 2.4 <jats:italic>vs<\/jats:italic> 4.6 \u00b1 2.3 <jats:italic>(P<\/jats:italic>= 0.006). Salmeterol was significantly more effective than SR\u2010terbutaline in the following factors: number of patients without any awakening during the last week of treatment (50%<jats:italic>vs<\/jats:italic> 27%, <jats:italic>P =<\/jats:italic> 0.003), mean morning PEF (351 \u00b1 1091\/min<jats:sup>\u20101<\/jats:sup><jats:italic>vs<\/jats:italic> 332 + 105 I\/min<jats:sup>\u20101<\/jats:sup>, <jats:italic>P<\/jats:italic>= 0.04), PEF diurnal variation 6 \u00b1 10%<jats:italic>vs<\/jats:italic> 11 \u00b1 12%, <jats:italic>P<\/jats:italic>= 0.01), overall assessment of efficacy by the patient and the investigator <jats:italic>(P<\/jats:italic>= 0.001 and 0.005, respectively), and daily rescue salbutamol intakes (<jats:italic>P<\/jats:italic>=0.004). In the salmeterol group, significantly fewer patients reported adverse events (16%<jats:italic>vs<\/jats:italic> 29%, <jats:italic>P<\/jats:italic>= 0.04). This study confirms that salmeterol, 50 \u03bcg twice daily, is particularly useful in controlling nocturnal symptoms of asthma: as compared with the control group, twice as many salmeterol\u2010treated patients were totally free of nocturnal symptoms after 2 weeks of treatment.<\/jats:p>","DOI":"10.1111\/j.1398-9995.1994.tb00834.x","type":"journal-article","created":{"date-parts":[[2007,5,14]],"date-time":"2007-05-14T00:08:21Z","timestamp":1179101301000},"page":"421-426","source":"Crossref","is-referenced-by-count":31,"title":["Salmeterol compared with slow\u2010release terbutaline in nocturnal asthma A multicenter, randomized, double\u2010blind, double\u2010dummy, sequential clinical trial"],"prefix":"10.1111","volume":"49","author":[{"given":"C.","family":"Brambilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Chastang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Georges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bertin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"French Multicenter Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dr 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