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S1 nuclease mapping shows multiple transcription initiation sites between nucleotides \u2013 367 and \u2013 387. A fragment encompassing 360 nucleotides of the flanking sequence upstream of the transcription initiation site shows promoter activity when it was transiently expressed in COS cells using the gene for bacterial chloramphenicol acetyltransferase as a reporter gene. This putative promoter region shows four potential Sp1 binding sites but lacks typical TATA and CAAT box sequences. Three different mRNA species of 2.1, 3.7 and 4.8 kb are transcribed from the gene and arise probably from the use of different polyadenylation signals.<\/jats:p>","DOI":"10.1111\/j.1432-1033.1990.tb19167.x","type":"journal-article","created":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T04:11:32Z","timestamp":1109909492000},"page":"627-631","source":"Crossref","is-referenced-by-count":86,"title":["Structure of the arylsulfatase A gene"],"prefix":"10.1111","volume":"191","author":[{"given":"Joachim","family":"KREYSING","sequence":"first","affiliation":[]},{"given":"Kurt","family":"von FIGURA","sequence":"additional","affiliation":[]},{"given":"Volkmap","family":"GIESELMANN","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,3,3]]},"reference":[{"key":"e_1_2_3_2_2","volume-title":"Molecular cloning: a laboratory manual","author":"Maniatis T","year":"1982"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)85079-2"},{"key":"e_1_2_3_4_2","first-page":"277","volume-title":"Basic methods in molecular biology","author":"Davis L. 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