{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:32:19Z","timestamp":1775277139881,"version":"3.50.1"},"reference-count":75,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,3,23]],"date-time":"2009-03-23T00:00:00Z","timestamp":1237766400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is conflicting data regarding the clinicopathological significance of the risk factors associated with Epstein\u2013Barr virus (EBV)\u2010associated gastric carcinoma (EBVaGC). To address this controversy, we performed a meta\u2010analysis for the clinicopathological and molecular characteristics of EBVaGC. The relevant published studies were reviewed according to the defined selection criteria. The effect sizes of the outcome parameters were estimated by an odds ratio or a weighted mean difference. This meta\u2010analysis included 48 studies that encompassed a total of 9738 patients. The frequency of EBVaGC was 8.8%, and EBVaGC was significantly associated with ethnicity. It was more predominant in men and in younger individuals. Interestingly, EBVaGC was more prevalent in Caucasian and Hispanic patients than in Asian ones. EBVaGC developed most often in the cardia and body, and it generally showed the diffuse histological type. EBV was highly prevalent in the patients with lymphoepithelial carcinoma. EBVaGC was closely associated with remnant cancer and a CpG island methylator\u2010high status, but not with <jats:italic>Helicobacter pylori<\/jats:italic> infection, a TP53 expression, and <jats:italic>p53<\/jats:italic> mutation. In addition, EBVaGC was not significantly associated with the depth of invasion, lymph node metastasis, or the clinical stage. The clinicopathological and molecular characteristics of EBVaGC are quite different from those of conventional gastric adenocarcinoma. However, further study is needed to determine the effect of EBV on the survival of EBVaGC patients.<\/jats:p>","DOI":"10.1111\/j.1440-1746.2009.05775.x","type":"journal-article","created":{"date-parts":[[2009,3,22]],"date-time":"2009-03-22T23:17:45Z","timestamp":1237763865000},"page":"354-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":207,"title":["Clinicopathological and molecular characteristics of Epstein\u2013Barr virus\u2010associated gastric carcinoma: A meta\u2010analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Ju\u2010Han","family":"Lee","sequence":"first","affiliation":[]},{"given":"Seo\u2010Hee","family":"Kim","sequence":"additional","affiliation":[]},{"given":"Sun\u2010Hee","family":"Han","sequence":"additional","affiliation":[]},{"given":"Jung\u2010Suk","family":"An","sequence":"additional","affiliation":[]},{"given":"Eung\u2010Seok","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Young\u2010Sik","family":"Kim","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2009,3,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-0670-3"},{"key":"e_1_2_5_3_2","first-page":"377","article-title":"Lymphoepithelial carcinoma of the stomach with Epstein\u2010Barr virus demonstrated by polymerase chain reaction","volume":"3","author":"Burke AP","year":"1990","journal-title":"Mod. Pathol"},{"key":"e_1_2_5_4_2","first-page":"769","article-title":"Epstein\u2010Barr virus\u2010associated gastric adenocarcinoma","volume":"140","author":"Shibata D","year":"1992","journal-title":"Am. J. Pathol"},{"key":"e_1_2_5_5_2","first-page":"1250","article-title":"Epstein\u2010Barr virus in gastric carcinoma","volume":"143","author":"Tokunaga M","year":"1993","journal-title":"Am. J. Pathol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1993.472"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.8.695"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1994.tb01350.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199411000-00010"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90056-X"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01209123"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/105.2.174"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.287333.x"},{"key":"e_1_2_5_14_2","first-page":"3081","article-title":"Discrepancy between clinical and pathological lymph node evaluation in Epstein\u2010Barr virus\u2010associated gastric cancers","volume":"16","author":"Ojima H","year":"1996","journal-title":"Anticancer Res"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90133-1"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970410)71:2<155::AID-IJC5>3.0.CO;2-#"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19971210)73:6<786::AID-IJC2>3.0.CO;2-Z"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(97)70265-7"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970822)74:4<450::AID-IJC16>3.0.CO;2-D"},{"key":"e_1_2_5_20_2","first-page":"191","article-title":"Deletion of Epstein\u2010Barr virus latent membrane protein 1 gene in Japanese and Brazilian gastric carcinomas, metastatic lesions, and reactive lymphocytes","volume":"152","author":"Hayashi K","year":"1998","journal-title":"Am. J. Pathol"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050299"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1999.00686.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008171006400"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90145-4"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00843.x"},{"key":"e_1_2_5_26_2","first-page":"2745","article-title":"Unique transcription pattern of Epstein\u2010Barr virus (EBV) in EBV\u2010carrying gastric adenocarcinomas: expression of the transforming BARF1 gene","volume":"60","author":"Zur Hausen A","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70355-6"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00052"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2001.tb01180.x"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1510"},{"key":"e_1_2_5_31_2","first-page":"1856","article-title":"Circulating Epstein\u2010Barr virus DNA in the serum of patients with gastric carcinoma","volume":"7","author":"Lo YM","year":"2001","journal-title":"Clin. Cancer Res"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10215"},{"key":"e_1_2_5_33_2","first-page":"1293","article-title":"The Epstein\u2010Barr virus\u2010associated gastric carcinoma in Southern and Northern China","volume":"9","author":"Hao Z","year":"2002","journal-title":"Oncol. Rep"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2152"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64901-2"},{"key":"e_1_2_5_36_2","first-page":"1059","article-title":"Epstein\u2010Barr virus\u2010associated gastric carcinoma in Cali, Colombia","volume":"10","author":"Carrascal E","year":"2003","journal-title":"Oncol. Rep"},{"key":"e_1_2_5_37_2","first-page":"123","article-title":"EBV\u2010positive gastric carcinomas in Poland","volume":"54","author":"Czopek JP","year":"2003","journal-title":"Pol. J. Pathol"},{"key":"e_1_2_5_38_2","first-page":"45","article-title":"Epstein\u2010Barr virus (EBV) and gastric carcinoma in Malaysian patients","volume":"25","author":"Karim N","year":"2003","journal-title":"Malays. J. Pathol"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-003-0247-2"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.061"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2004001100016"},{"key":"e_1_2_5_42_2","first-page":"1093","article-title":"Epstein\u2010Barr virus\u2010associated gastric carcinoma in Papua New Guinea","volume":"12","author":"Morewaya J","year":"2004","journal-title":"Oncol. Rep"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i1.27"},{"key":"e_1_2_5_44_2","first-page":"49","article-title":"Epstein\u2010Barr virus\u2010associated gastric carcinoma in Lima, Peru","volume":"24","author":"Yoshiwara E","year":"2005","journal-title":"J. Exp. Clin. Cancer Res"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20903"},{"key":"e_1_2_5_46_2","first-page":"379","article-title":"Epstein\u2010Barr virus detection in tumors of upper gastrointestinal tract. An in situ hybridization study in Pakistan","volume":"24","author":"Anwar M","year":"2005","journal-title":"J. Exp. Clin. Cancer Res"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i39.6096"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i12.1842"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i31.4959"},{"key":"e_1_2_5_50_2","first-page":"633","article-title":"Environmental factors related to gastric cancer associated with Epstein\u2010Barr virus in Colombia","volume":"7","author":"Campos FI","year":"2006","journal-title":"Asian Pac. J. Cancer Prev"},{"key":"e_1_2_5_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-2-25"},{"key":"e_1_2_5_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940801)74:3<805::AID-CNCR2820740304>3.0.CO;2-L"},{"key":"e_1_2_5_53_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2000.01072.x"},{"key":"e_1_2_5_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22754"},{"key":"e_1_2_5_55_2","doi-asserted-by":"publisher","DOI":"10.1080\/713786518"},{"key":"e_1_2_5_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-005-1590-3"},{"key":"e_1_2_5_57_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.014068"},{"key":"e_1_2_5_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1997.tb04509.x"},{"key":"e_1_2_5_59_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199907000-00010"},{"key":"e_1_2_5_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s101200050031"},{"key":"e_1_2_5_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1997.tb00376.x"},{"key":"e_1_2_5_62_2","first-page":"311","article-title":"p53 overexpression is different in Epstein\u2010Barr virus\u2010associated and Epstein\u2010Barr virus\u2010negative carcinoma","volume":"33","author":"Leung SY","year":"1998","journal-title":"Histopathology"},{"key":"e_1_2_5_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-001-0566-9"},{"key":"e_1_2_5_64_2","first-page":"635","article-title":"Prognostic significance of Epstein\u2010Barr virus involvement in gastric carcinoma in Japan","volume":"10","author":"Koriyama C","year":"2002","journal-title":"Int. J. Mol. Med"},{"key":"e_1_2_5_65_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.015081"},{"key":"e_1_2_5_66_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i21.3234"},{"key":"e_1_2_5_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2005.12.001"},{"key":"e_1_2_5_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22275"},{"key":"e_1_2_5_69_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.884"},{"key":"e_1_2_5_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21789"},{"key":"e_1_2_5_71_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1601"},{"key":"e_1_2_5_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00625.x"},{"key":"e_1_2_5_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(03)00410-5"},{"key":"e_1_2_5_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.00888.x"},{"key":"e_1_2_5_75_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-3027"},{"key":"e_1_2_5_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1864"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1746.2009.05775.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1746.2009.05775.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T05:34:13Z","timestamp":1697348053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1746.2009.05775.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":75,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1111\/j.1440-1746.2009.05775.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1746.2009.05775.x","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"2009-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}