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The chromosomal translocation t(11;14)(q<jats:bold>13<\/jats:bold>:q32), Involving rearrangement of the <jats:italic>BCL\u20101<\/jats:italic> locus, is closely associated wlth human lymphoid neoplasia affecting mantle cell lymphomas (MCL). Recently, the putative <jats:italic>BCL\u20101<\/jats:italic> protosncogene turned out to be none other than the cydin D1 gene. Although the observed break points In the <jats:italic>BCL\u20107<\/jats:italic> locus are not tightly clustered, Its rearrangement has been documented In 40\u201370% of cases of mantle cell lymphoma, whereas it only rarely occurs in other B cell lymphomas. Of note, all of the known break points leave the cyclin D1 coding region structurally Intact and result In increased protein expression, implying that this may provide a highly sensitive and specific marker for MCL. Recent studies demonstrated that immunohistochemical detection In paraffin\u2010embedded material, using a mone clonal antibody, Is very useful for routine diagnosis. Current knowledge of cydin D1 over expression In malignant lymphomas, with emphasis on its clinic pathologic significance, is reviewed.<\/jats:p>","DOI":"10.1111\/j.1440-1827.1997.tb04519.x","type":"journal-article","created":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T14:30:48Z","timestamp":1229092248000},"page":"421-429","source":"Crossref","is-referenced-by-count":37,"title":["Cyclin D1 over expression in malignant 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