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Three groups of mGluRs have been described: group 1 (mGluR1 and 5) receptors are positively coupled to phospholipase C whereas group 2 (mGluR2 and 3) and group 3 (mGluR4, 6, 7 and 8) receptors are negatively coupled to adenylate cyclase. We found that the broad\u2010spectrum agonist (1<jats:italic>S<\/jats:italic>,3R)\u20101\u2010aminocyclopentyl\u20101,3\u2010dicarboxylate and the group 1\u2010specific agonist (<jats:italic>R,S<\/jats:italic>)\u2010dihydroxyphenylglycine both reversibly inhibited evoked field excitatory postsynaptic potentials, indicating the involvement of group 1 mGluRs. (<jats:italic>R,S<\/jats:italic>)\u20103,5\u2010dihydroxyphenylglycine presumably inhibited transmission via a presynaptic mechanism, as whole\u2010cell voltage\u2010clamp recordings revealed that inhibition of the synaptic transmission was always accompanied with an increase in paired\u2010pulse facilitation. Treatment with a specific blocker of mGluR1 receptors, the phenylglycine derivative (<jats:italic>S<\/jats:italic>)\u20104\u2010carboxyphenylglycine, was without effect on the (1<jats:italic>S<\/jats:italic>,3<jats:italic>R<\/jats:italic>)\u20101\u2010amino\u2010cyclopentyl\u20101,3\u2010dicarboxylate\u2010induced depression of the field excitatory postsynaptic potentials, strongly suggesting that mGluR5 receptors are responsible for the (1<jats:italic>S<\/jats:italic>,3<jats:italic>R<\/jats:italic>)\u20101\u2010aminocyclopentyl\u20101,3\u2010dicarboxylate effect. Two selective agonists of group 2 mGluRs, (2<jats:italic>S<\/jats:italic>,1\u2032<jats:italic>s<\/jats:italic>,2\u2032<jats:italic>s<\/jats:italic>)\u20102\u2010(2\u2032\u2010carboxycyclopropyl)glycine and 4\u2010carboxy\u20103\u2010hydroxyphenylglycine, were totally ineffective in blocking CA3\u2010CA1\u2010evoked synaptic transmission, excluding the involvement of mGluR2\/3 subtypes at this developmental stage.<\/jats:p>","DOI":"10.1111\/j.1460-9568.1995.tb01051.x","type":"journal-article","created":{"date-parts":[[2006,4,8]],"date-time":"2006-04-08T01:37:57Z","timestamp":1144460277000},"page":"2518-2523","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Metabotropic Glutamate Receptors Inhibiting Excitatory Synapses in the CA1 Area of Rat Hippocampus"],"prefix":"10.1111","volume":"7","author":[{"given":"Olivier","family":"Manzoni","sequence":"first","affiliation":[]},{"given":"Jo\u00ebl","family":"Bockaert","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,4,7]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90204-6"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018901"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(89)90131-3"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(95)00079-L"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(95)00012-U"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(95)00082-H"},{"key":"e_1_2_2_8_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1152\/jn.1989.61.1.218","article-title":"Measurement of passive membrane parameters with whole\u2010cell recording from neurons in the intact amphibian retina","volume":"61","author":"Coleman P. 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