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In this study, we have investigated KA\u2010elicited limbic seizures in the rats by correlating the severity of the seizure attacks with the expression of hippocampal heat shock protein\u201070 (HSP70) which has been suggested to be a marker for neuronal injury\/death in this model of seizures. After a systemic injection of KA, six stages of limbic seizures have been classified, namely, staring (stage 1), wet dog shake (stage 2), hyperactivity (stage 3), rearing (stage 4), rearing and falling (stage 5), and jumping (stage 6). Stages 4, 5 and 6 were further divided into mild and severe sub\u2010stages. HSP70 expression was not detected in animals with stages 1 and 2 seizures. At stage 3 a small amount of HSP70 immunoreactive neurons was detected in the CA3 field and the dentate hilus. From stage 4 to stage 5 the degree of HSP70 immunoreactivity increased in the CA1 field from a few positive cells in stage 4 mild to large numbers of immunoreactive neurons in stage 5 severe. HSP70 became detectable in pyramidal cells in the CA2 field from stage 5 severe and higher. In animals with stage 6 seizures, the majority of HSP70 expression became located in glial cells throughout the whole hippocampus. We concluded that HSP70 expression in the hippocampus positively correlates with the severity of KA\u2010elicited limbic seizures.<\/jats:p>","DOI":"10.1111\/j.1460-9568.1997.tb01424.x","type":"journal-article","created":{"date-parts":[[2006,4,8]],"date-time":"2006-04-08T02:37:10Z","timestamp":1144463830000},"page":"760-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Gradation of Kainic Acid\u2010induced Rat Limbic Seizures and Expression of Hippocampal Heat Shock Protein\u201070"],"prefix":"10.1111","volume":"9","author":[{"given":"Xia","family":"Zhang","sequence":"first","affiliation":[]},{"given":"Douglas L.","family":"Gelowitz","sequence":"additional","affiliation":[]},{"given":"Chien\u2010Tsai","family":"Lai","sequence":"additional","affiliation":[]},{"given":"Alan A.","family":"Boulton","sequence":"additional","affiliation":[]},{"given":"Peter H.","family":"Yu","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,4,7]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"685","article-title":"The inducible 70, 000 molecular weight heat shock protein is expressed in the degenerating dentate hilus and piriform cortex after systemic administration of kainic acid in the rat","volume":"74","author":"Armstrong T.N.","year":"1996","journal-title":"Neuron"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90299-4"},{"key":"e_1_2_2_4_1","first-page":"1361","article-title":"Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazol: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy","volume":"6","author":"Ben\u2010Ari Y.","year":"1981","journal-title":"Neuron"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90044-5"},{"key":"e_1_2_2_6_1","first-page":"471","article-title":"The proliferation of astrocytes around a needle wound in the rat brain","volume":"106","author":"Cavanagh T. 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