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We also have the first evidence that induction of human <jats:italic>PER2<\/jats:italic> expression is stimulated by exposing subjects to 2\u2003h of light in the evening. This increase in <jats:italic>PER2<\/jats:italic> expression was statistically significant in comparison to a non\u2010light control condition only after light at 460\u2003nm (blue) but not after light exposure at 550\u2003nm (green). Our results indicate that the non\u2010image\u2010forming visual system is involved in human circadian gene expression. The demonstration of a functional circadian machinery in human buccal samples and its response to light opens the door for investigation of human circadian rhythms at the gene level and their associated disorders.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2006.04613.x","type":"journal-article","created":{"date-parts":[[2006,2,8]],"date-time":"2006-02-08T11:39:14Z","timestamp":1139398754000},"page":"1082-1086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["Evening exposure to blue light stimulates the expression of the clock gene <i>PER2<\/i> in 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