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Low doses of irradiation (IRR) produce a significant long\u2010lasting inhibitory effect on hippocampal neurogenesis that correlates with long\u2010lasting behavioral deficits. Here we report that electroconvulsive seizure (ECS), which robustly increases adult neurogenesis in na\u00efve animals, also reverses the disruption of neurogenesis produced by IRR exposure. Moreover, we find that vascular endothelial growth factor (VEGF) is an essential mediator of this effect. Expression of VEGF in the granule cell layer (GCL) of the hippocampus is decreased by IRR, and ECS administration reverses this deficit in VEGF. There is a corresponding alteration in the number of endothelial cells, which express VEGF, in the hippocampal GCL following IRR and ECS. We also find that blockade of VEGF signaling attenuates ECS\u2010induced proliferation, and VEGF infusion partially restores proliferation in irradiated animals. To examine the functional consequences of IRR and ECS on neurogenesis, hippocampus\u2010dependent contextual fear conditioning was assessed. We found that following disruption by IRR, ECS restores contextual learning to baseline levels at time points consistent with its effects on neurogenesis. These findings demonstrate that ECS, in part via induction of VEGF, can reverse long\u2010term neurogenesis deficits resulting from IRR, and that these effects have functional consequences on hippocampus\u2010dependent fear memory.<\/jats:p>","DOI":"10.1111\/j.1460-9568.2008.06118.x","type":"journal-article","created":{"date-parts":[[2008,3,11]],"date-time":"2008-03-11T04:11:19Z","timestamp":1205208679000},"page":"1485-1493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Electroconvulsive seizure restores neurogenesis and hippocampus\u2010dependent fear memory after disruption by irradiation"],"prefix":"10.1111","volume":"27","author":[{"given":"Jennifer L.","family":"Warner\u2010Schmidt","sequence":"first","affiliation":[]},{"given":"Torsten M.","family":"Madsen","sequence":"additional","affiliation":[]},{"given":"Ronald 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