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The results demonstrated a progressive accumulation of lactate as well as of pyruvate and malate in the absence of changes in ATP, A DP, AMP, citrate and ammonia. The pattern of substrate changes obtained indicate that hypoxia is accompanied by activation of pyruvate kinase and of hexokinase, but not of phosphofructokinase. There was a progressive fall in intracellular pH and a moderate increase in the calculated cytoplasmic NADH\/NAD<jats:sup>+<\/jats:sup> ratio. The changes in pyruvate and in the NADH\/NAD<jats:sup>+<\/jats:sup> ratio may be responsible for the observed increase in the malate concentration.<\/jats:p>","DOI":"10.1111\/j.1471-4159.1974.tb07605.x","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T03:54:49Z","timestamp":1160020489000},"page":"395-401","source":"Crossref","is-referenced-by-count":84,"title":["MECHANISMS ACTIVATING GLYCOLYSIS IN THE BRAIN IN ARTERIAL HYPOXIA"],"prefix":"10.1111","volume":"22","author":[{"given":"H. 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