{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:47:06Z","timestamp":1769608026662,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,12]],"date-time":"2006-12-12T00:00:00Z","timestamp":1165881600000},"content-version":"vor","delay-in-days":7956,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:p><jats:bold>Abstract: <\/jats:bold> We have observed recently that <jats:italic>in vitro<\/jats:italic> lipoperoxidation is enhanced in Down's syndrome brain homogenates of prenatal age. As this may relate to the composition of polyunsaturated acyl groups (PUFA) in phospholipids, we have examined the PUFA of ethanolamine and serine phosphoglycerides (EPG and SPG), which are particularly rich in PUFA, in the same series of cerebral cortex specimens of Down's syndrome and age\u2010matched control fetuses. Although the total percentages of PUFA in the two phosphoglycerides were not altered, compared with controls the ratio of PUFA of the (n\u20103) series to those of the (n\u20106) series was very significantly elevated in Down's syndrome, from 0.32 to 0.55 in EPG and from 0.60 to 0.97 in SPG. In particular, docosahexaenoyl, 22:6(n\u20103), groups were uniformly increased in Down's syndrome compared with controls by 54% and 33% in EPG and SPG, respectively, while arachidonoyl, 20:4(n\u20106), groups were decreased by 16% and 30%, respectively. Similar changes occur during normal development, but the (n\u20103) to (n\u20106) ratio of PUFA in these phosphoglycerides of Down's syndrome at the fifth month of gestation resembled that of normal human cerebral grey matter at term. However, other developmental indices related to PUFA composition were not significantly affected. It seems therefore that in the developing Down's syndrome brain there may be a distortion of the normal transformations of essential fatty acids and of their incorporation into phosphoglycerides. The disproportion between docosahexaenoyl and arachidonoyl groups in membrane phosphoglycerides during prenatal development in Down's syndrome may also result in disturbances of the proper functioning, and the ontogenetic integration, of membrane enzymes and transport processes.<\/jats:p>","DOI":"10.1111\/j.1471-4159.1985.tb12896.x","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T12:10:35Z","timestamp":1166011835000},"page":"869-874","source":"Crossref","is-referenced-by-count":31,"title":["Altered Composition of Polyunsaturated Fatty Acyl Groups in Phosphoglycerides of Down's Syndrome Fetal Brain"],"prefix":"10.1111","volume":"44","author":[{"given":"B. W. L.","family":"Brooksbank","sequence":"first","affiliation":[]},{"given":"Manuela","family":"Martinez","sequence":"additional","affiliation":[]},{"given":"R.","family":"Balazs","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,12,12]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"91","volume-title":"Handbook of Neurochemistry","author":"Abdel\u2010Latif A. A.","year":"1983"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1973.tb07559.x"},{"key":"e_1_2_2_4_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/jn\/102.6.773","article-title":"Effect of maternal essential fatty acid supply on fatty acid composition of brain, liver, muscle and serum in 21\u2010day\u2010old rats","volume":"102","author":"Ailing C.","year":"1972","journal-title":"J. Nutr."},{"key":"e_1_2_2_5_1","unstructured":"BallabrigaA.andMartinezM.(1975)Changes in organ chemical composition during parertteral nutrition.3e Giornate di Studio Plasmon Problemi Attuali di Nutrizione in Pediatria Sanremo. pp.115\u2013125."},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90541-3"},{"key":"e_1_2_2_7_1","first-page":"17","volume-title":"Handbook of Neurochemistry","author":"Bazan N. G.","year":"1983"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91427-7"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(84)90060-9"},{"key":"e_1_2_2_10_1","first-page":"395","article-title":"The long chain metabolites of linoleic and linolenic acids in liver and brain in herbivores and carnivores","volume":"54","author":"Crawford M. A.","year":"1976","journal-title":"Comp. Biochem. Physiol."},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91476-8"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(62)90181-9"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/30.6.647"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1977.tb00303.x"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(71)90233-5"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)82628-X"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90046-5"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00965025"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00963913"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1977.00500170042008"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(82)90034-X"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(75)90006-5"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-008304-6.50014-2"},{"key":"e_1_2_2_24_1","first-page":"256","article-title":"Correlated changes in the polyunsaturated fatty acid patterns of brain and liver phosphoglycerides in newborn infants with different gestational ages, XIV International Congress of Pediatrics","volume":"5","author":"Martinez M.","year":"1974","journal-title":"Buenos Aires"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197402000-00005"},{"key":"e_1_2_2_26_1","first-page":"121","article-title":"Vitamin E concentrations in brains from fetuses with Down's syndrome","volume":"12","author":"Metcalfe T.","year":"1984","journal-title":"IRCS Med. Sci."},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1981.tb04498.x"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(81)90132-4"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000176649"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000176665"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(83)90313-9"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0079-6107(81)90011-0"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1980.tb11254.x"},{"key":"e_1_2_2_34_1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0022-2275(20)39795-9","article-title":"Synthesis of molecular species of glycerophospholipids from diglyceride\u2010labelled brain microsomes","volume":"21","author":"Roberti R.","year":"1980","journal-title":"J. Lipid Res."},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02635576"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1982.tb11510.x"},{"key":"e_1_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4157(78)90015-1"},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(81)90036-5"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(79)90002-8"},{"key":"e_1_2_2_40_1","first-page":"307","article-title":"The adrenergic responsiveness of Down syndrome cells","volume":"97","author":"Sheppard J. R.","year":"1982","journal-title":"Progr. Clin. Biol. Res."},{"key":"e_1_2_2_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1972.tb06219.x"},{"key":"e_1_2_2_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb26845.x"},{"key":"e_1_2_2_43_1","first-page":"656","article-title":"Phospholipids and acyl groups in subcellular fractions from human cerebral cortex","volume":"14","author":"Sun G. Y.","year":"1973","journal-title":"J. LipidRes."},{"key":"e_1_2_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)42702-6"},{"key":"e_1_2_2_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90652-X"},{"key":"e_1_2_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90735-X"},{"key":"e_1_2_2_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90314-0"},{"key":"e_1_2_2_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-566504-9.50016-7"},{"key":"e_1_2_2_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000241174"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1471-4159.1985.tb12896.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1471-4159.1985.tb12896.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T15:44:20Z","timestamp":1697816660000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1471-4159.1985.tb12896.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,3]]}},"alternative-id":["10.1111\/j.1471-4159.1985.tb12896.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1471-4159.1985.tb12896.x","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3]]}}}