{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:07:12Z","timestamp":1759032432679},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,12]],"date-time":"2006-12-12T00:00:00Z","timestamp":1165881600000},"content-version":"vor","delay-in-days":7650,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:p><jats:bold>Abstract: <\/jats:bold> 3,4\u2010Dihydroxyphenylethylamine (DA, dopamine) levels in the rat prefrontal cortex were selectively decreased by 52%, leaving noradrenaline (NA) levels unaffected, 4 weeks following restricted bilateral electrolytic lesions of the ventral mesencephalic tegmentum (VMT). These lesions also induced a significant increase in DA\u2010sensitive, but not isoproterenol\u2010sensitive, adenylate cyclase activity in tissue homogenates (+ 38%). We had shown previously that chemical (6\u2010hydroxydo\u2010pamine, 6\u2010OHDA) lesions of the VMT destroy both ascending DA and NA fibers but do not alter the D<jats:sub>1<\/jats:sub>\u2010receptor density in the prefrontal cortex. In this study, electrolytic lesions of the VMT were combined with bilateral injections of 6\u2010OHDA made laterally in the pedunculus cerebellaris superior to assess the role of NA fibers in the development of D<jats:sub>1<\/jats:sub>\u2010receptor supersensitivity. This combined treatment produces a large decrease of cortical NA levels (\u201095%), an increase in \u03b2\u2010adrenergic\u2010sensitive adenylate cyclase activity (+110%), and a decrease in DA levels (\u2010 60%), but does not alter D<jats:sub>1<\/jats:sub>\u2010receptor density in the prefrontal cortex. These results indicate that the development of D<jats:sub>1<\/jats:sub>\u2010receptor supersensitivity in the prefrontal cortex following electrolytic lesion of the VMT depends on the presence of an intact NA innervation.<\/jats:p>","DOI":"10.1111\/j.1471-4159.1986.tb12953.x","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T11:58:06Z","timestamp":1166011086000},"page":"243-248","source":"Crossref","is-referenced-by-count":71,"title":["Contribution of Noradrenergic Neurons to the Regulation of Dopaminergic (D<sub>1<\/sub>) Receptor Denervation Supersensitivity in Rat Prefrontal Cortex"],"prefix":"10.1111","volume":"46","author":[{"given":"J. P.","family":"Tassin","sequence":"first","affiliation":[]},{"given":"J. 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