{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T05:31:58Z","timestamp":1763443918868},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T00:00:00Z","timestamp":1160006400000},"content-version":"vor","delay-in-days":6639,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[1988,8]]},"abstract":"<jats:p><jats:bold>Abstract: <\/jats:bold> High\u2010performance liquid chromatography with electrochemical detection was used to measure the concentrations of 3,4\u2010dihydroxyphenylethylamine (dopamine), 5\u2010hydroxytryptamine (5\u2010HT), <jats:italic>p<\/jats:italic>\u2010hydroxyphenylethanolamine (octopamine), \u03b1\u2010methyl\u2010<jats:italic>p<\/jats:italic>\u2010tyrosine, and tryptophan in the cerebral ganglia of cockroaches (<jats:italic>Periplaneta americana<\/jats:italic>) after peripheral administration of \u03b1\u2010methyl\u2010<jats:italic>p<\/jats:italic>\u2010tyrosine and \u03b1\u2010methyltryptophan. In addition, the levels of dopamine, 5\u2010HT, octopamine, \u03b1\u2010methyl\u2010<jats:italic>p<\/jats:italic>\u2010tyrosine, and tryptophan were determined after injection of \u03b1\u2010methyl\u2010<jats:italic>p<\/jats:italic>\u2010tyrosine, 6\u2010hydroxydopamine, or 5,7\u2010dihydroxytryptamine directly into the cerebral ganglia by means of microinjection needles. Peripheral administration of \u03b1\u2010methyl\u2010<jats:italic>p<\/jats:italic>\u2010tyrosine (400\u20131,600 \u03bcg\/insect) caused a reduction in dopamine and 5\u2010HT concentrations in cockroach cerebral ganglia, although the reduction in dopamine concentrations was more pronounced. Peripheral injections of \u03b1\u2010methyl\u2010<jats:italic>p<\/jats:italic>\u2010tyrosine also reduced octopamine levels in the cerebral ganglia. Peripheral injection of \u03b1\u2010methyltryptophan (400\u20131,600 \u03bcg\/insect) caused a marked reduction in 5\u2010HT and tryptophan concentrations in cockroach cerebral ganglia without altering dopamine or octopamine concentrations. Central injections of \u03b1\u2010methyl\u2010<jats:italic>p<\/jats:italic>\u2010tyrosine (80 \u03bcg\/insect) reduced dopamine concentrations in the cerebral ganglia. However, neither 6\u2010hydroxydopamine (20 \u03bcg\/insect) nor 5,7\u2010dihydroxytryptamine (20 \u03bcg\/insect) caused reductions in amine levels when applied near or directly into the cerebral ganglia. The results suggest that specific lesions of aminergic neurons in insects by either 6\u2010hydroxydopamine or 5,7\u2010dihydroxytryptamine are impractical. The specific, long\u2010lasting depletion of 5\u2010HT by \u03b1\u2010methyltryptophan suggests that this chemical may be useful in elucidating the functions of 5\u2010HT in insects.<\/jats:p>","DOI":"10.1111\/j.1471-4159.1988.tb01071.x","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T21:57:14Z","timestamp":1160085434000},"page":"535-541","source":"Crossref","is-referenced-by-count":35,"title":["Selective Depletion of Dopamine, Octopamine, and 5\u2010Hydroxytryptamine in the Nervous Tissue of the Cockroach (<i>Periplaneta americana<\/i>)"],"prefix":"10.1111","volume":"51","author":[{"given":"B. 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