{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:58:26Z","timestamp":1758279506641},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,12]],"date-time":"2006-12-12T00:00:00Z","timestamp":1165881600000},"content-version":"vor","delay-in-days":6189,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:p><jats:bold>Abstract: <\/jats:bold> The effect of angiotensin II on the cytosolic free Ca<jats:sup>2+<\/jats:sup> concentration was measured in single mouse neuroblastoma N1E\u2010115 cells loaded with fura\u20102. Angiotensin II induced a transient concentration\u2010dependent increase in Ca<jats:sup>2+<\/jats:sup> and also increased the production of inositol polyphosphates. The Ca<jats:sup>2+<\/jats:sup> increase did not require extracellular Ca<jats:sup>2+<\/jats:sup> and was unaffected by pretreatment with pertussis toxin. These data suggest that angiotensin II increased Ca<jats:sup>2+<\/jats:sup> by an inositol tris\u2010phosphate\u2010mediated release of intracellular Ca<jats:sup>2+<\/jats:sup> following activation of phospholipase C via a pertussis toxin\u2010insensitive guanine nucleotide binding protein. Similar results were obtained with bradykinin. The angiotensin II\u2010 or bradykinin\u2010induced increase in Ca<jats:sup>2+<\/jats:sup> occurred after a concentration\u2010dependent latent period. Low concentrations of agonist elicited a small increase in Ca<jats:sup>2+<\/jats:sup> following a variable lag that sometimes exceeded 1 min, whereas at maximally effective angiotensin II concentrations a larger, more rapid increase in Ca<jats:sup>2+<\/jats:sup> occurred without a measurable delay. In some cells, oscillatory increases in Ca<jats:sup>2+<\/jats:sup> were induced by angiotensin II and bradykinin. Possible mechanisms to explain the concentration dependency of the latent period and the oscillatory nature of the increases of Ca<jats:sup>2+<\/jats:sup> are discussed. These results indicate that the mouse neuroblastoma N1E\u2010115 cell represents a useful model for studying the signal response transduction mechanisms regulating the effects of angiotensin II in neuronal cells.<\/jats:p>","DOI":"10.1111\/j.1471-4159.1990.tb13312.x","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T06:05:57Z","timestamp":1165989957000},"page":"278-287","source":"Crossref","is-referenced-by-count":28,"title":["Angiotensin II Effects on the Cytosolic Free Ca<sup>2+<\/sup> Concentration in N1E\u2010115 Neuroblastoma Cells: Kinetic Properties of the Ca<sup>2+<\/sup> Transient Measured in Single Fura\u20102\u2010Loaded Cells"],"prefix":"10.1111","volume":"54","author":[{"given":"Jonathan R.","family":"Monck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Rogulja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Fluharty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,12]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/S0021-9258(19)77971-X","article-title":"Agonist\u2010stimulated oscillations and cycling of intracellular free calcium in individual cultured muscle cells","volume":"263","author":"Ambler S. 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