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The ganglioside composition became simpler during development with an increasing amount of GM1 and decreasing percentages of di\u2010and polysialogangliosides. The decrease in the proportion of GD1a was most prominent, whereas relative amounts of GD1b and GT1b increased transiently before reducing to the adult levels. The heavy myelin subfraction contained higher percentages of di\u2010and polysialo\u2010species compared to the light myelin fraction at young and adult ages. The in vitro incubation of myelin of young rats under an optimal condition for neuraminidase action produced a profile of ganglioside changes similar to that observed in in vivo development. These results strongly suggest that myelin\u2010associated neuraminidase may play a pivotal role in the developmental changes in the ganglioside composition of rat brain myelin.<\/jats:p>","DOI":"10.1111\/j.1471-4159.1992.tb09280.x","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T02:41:37Z","timestamp":1160102497000},"page":"83-87","source":"Crossref","is-referenced-by-count":31,"title":["Role of Myelin\u2010Associated Neuraminidase in the Ganglioside Metabolism of Rat Brain Myelin"],"prefix":"10.1111","volume":"58","author":[{"given":"Megumi","family":"Saito","sequence":"first","affiliation":[]},{"given":"Robert K.","family":"Yu","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,10,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90373-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-1200-0_20"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1016\/S0021-9258(18)34911-1","article-title":"Disialogangliosides in bovine adrenal medulla","volume":"257","author":"Ariga T.","year":"1982","journal-title":"J. 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