{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T12:34:55Z","timestamp":1726058095683},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,4,7]],"date-time":"2005-04-07T00:00:00Z","timestamp":1112832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A number of works show that the mitogen\u2010activated protein kinase (MAPK) signalling pathway responds actively in cerebral ischaemia and reperfusion. We undertook our present studies to clarify the role of mixed\u2010lineage kinase\u20033 (MLK3), a MAPK kinase kinase (MAPKKK) in MAPK cascades, in global ischaemia and ischaemic tolerance. The mechanism concerning NMDA receptor\u2010mediated Akt1 activation underlying ischaemic tolerance, was also investigated. Sprague\u2013Dawley rats were subjected to 6\u2003min of ischaemia and differing times of reperfusion. Our results showed MLK3 was activated in the hippocampal CA1 region with two peaks occurring at 30\u2003min and 6\u2003h, respectively. This activation returned to base level 3\u2003days later. Both preconditioning with 3\u2003min of sublethal ischaemia and NMDA pretreatment inhibited the 6\u2010h peak of activation. However, pretreatment of ketamine before preconditioning reversed the inhibiting effect of preconditioning on MLK3 activation at 6\u2003h of reperfusion. In the case of Akt1, however, preconditioning and NMDA pretreatment enhanced Akt1 activation at 10\u2003min of reperfusion. Furthermore, ketamine pretreatment reversed preconditioning\u2010induced increase of Akt1 activation. We also noted that pretreatment of LY294002 before preconditioning reversed both the inhibition of MLK3 activation at 6\u2003h of reperfusion and the increase in Akt1 activation at 10\u2003min of reperfusion. The above\u2010mentioned results lead us to conclude that, in the hippocampal CA1 region, preconditioning inhibits MLK3 activation after lethal ischaemia and reperfusion and, furthermore, this effect is mediated by Akt1 activation through NMDA receptor stimulation.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2005.03096.x","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T15:22:06Z","timestamp":1114615326000},"page":"1021-1029","source":"Crossref","is-referenced-by-count":39,"title":["Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed\u2010lineage kinase\u20033 via NMDA receptor\u2010mediated Akt1 activation"],"prefix":"10.1111","volume":"93","author":[{"given":"Xiao\u2010Hui","family":"Yin","sequence":"first","affiliation":[]},{"given":"Quan\u2010Guang","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Bei","family":"Miao","sequence":"additional","affiliation":[]},{"given":"Guang\u2010Yi","family":"Zhang","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,4,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211598200"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80595-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/376599a0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02188.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5392.1318"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90162-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480230915"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80405-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307357200"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90534-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5300.665"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02740604"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm906"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02006-0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200104170-00006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.1999.00287.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90871-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1991.62"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90189-I"},{"key":"e_1_2_7_21_1","unstructured":"Kiyokazuet al.(2003)."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb00103.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00901.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90013-X"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91380-W"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00523-3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn725"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(90)90184-A"},{"key":"e_1_2_7_29_1","doi-asserted-by":"crossref","first-page":"4949","DOI":"10.1523\/JNEUROSCI.21-14-04949.2001","article-title":"Evidence for a role of mixed lineage kinase in neuronal apoptosis","volume":"21","author":"Mota M.","year":"2001","journal-title":"J. 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